Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis
© 2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,ABSTRACT: This study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotecti...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Lippincott Williams & Wilkins
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/5409 |
| _version_ | 1848744788213366784 |
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| author | Biskou, O. Gardner-Medwin, J. Mackinder, M. Bertz, M. Clark, C. Svolos, V. Russell, R. Edwards, Christine McGrogan, P. Gerasimidis, K. |
| author_facet | Biskou, O. Gardner-Medwin, J. Mackinder, M. Bertz, M. Clark, C. Svolos, V. Russell, R. Edwards, Christine McGrogan, P. Gerasimidis, K. |
| author_sort | Biskou, O. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,ABSTRACT: This study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). Faecal calprotectin was measured in 232 children; 55 children (n?=?11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten free diet and 114 controls. None of the treatment-naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed CD patients, the median (IQR) FC was higher 36.4 (26–61) than in controls 25.0 (23–41) mg/kg (p?=?0.045) but this significantly decreased 25 (25–25) mg/kg (p?=?0.012) after six months on gluten free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation. |
| first_indexed | 2025-11-14T06:07:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-5409 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:07:01Z |
| publishDate | 2016 |
| publisher | Lippincott Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-54092018-12-14T00:46:04Z Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis Biskou, O. Gardner-Medwin, J. Mackinder, M. Bertz, M. Clark, C. Svolos, V. Russell, R. Edwards, Christine McGrogan, P. Gerasimidis, K. © 2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,ABSTRACT: This study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). Faecal calprotectin was measured in 232 children; 55 children (n?=?11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten free diet and 114 controls. None of the treatment-naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed CD patients, the median (IQR) FC was higher 36.4 (26–61) than in controls 25.0 (23–41) mg/kg (p?=?0.045) but this significantly decreased 25 (25–25) mg/kg (p?=?0.012) after six months on gluten free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation. 2016 Journal Article http://hdl.handle.net/20.500.11937/5409 10.1097/MPG.0000000000001384 Lippincott Williams & Wilkins restricted |
| spellingShingle | Biskou, O. Gardner-Medwin, J. Mackinder, M. Bertz, M. Clark, C. Svolos, V. Russell, R. Edwards, Christine McGrogan, P. Gerasimidis, K. Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis |
| title | Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis |
| title_full | Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis |
| title_fullStr | Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis |
| title_short | Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis |
| title_sort | faecal calprotectin in treated and untreated children with coeliac disease and juvenile idiopathic arthritis |
| url | http://hdl.handle.net/20.500.11937/5409 |