The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness
Background: Psychotropic medication use occurs in 8% of pregnancies, with rates increasing, and often multiple medications prescribed. Aims: This study aims to determine if the use of psychotropic medication, in a cohort of women with severe mental illness, increases rates of special care nursery ad...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Wiley-Blackwell Publishing Asia
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/53940 |
| _version_ | 1848759264530661376 |
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| author | Frayne, J. Nguyen, T. Bennett, K. Allen, S. Hauck, Yvonne Liira, H. |
| author_facet | Frayne, J. Nguyen, T. Bennett, K. Allen, S. Hauck, Yvonne Liira, H. |
| author_sort | Frayne, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Psychotropic medication use occurs in 8% of pregnancies, with rates increasing, and often multiple medications prescribed. Aims: This study aims to determine if the use of psychotropic medication, in a cohort of women with severe mental illness, increases rates of special care nursery admission and reports differences between antidepressant and antipsychotic medication use either alone or in combination. Methods: A retrospective database analysis from a cohort with severe mental illness in pregnancy identified 268 pregnant women who were grouped according to medication type. Demographic, obstetric and neonatal variables were analysed using t-tests, χ2, analysis of variance and logistic regression analysis for special care nursery admission. Results: The medication groups consisted of: women taking no psychotropic medications (n = 67); those taking antipsychotics (n = 87); those taking antidepressants (n = 55); those taking and a combination of antidepressants/antipsychotics (n = 59). Rates of special care nursery admission in women who took psychotropic medication (41.3%) were elevated compared to those who did not (26.9%) (P = 0.035), and were significantly raised when compared to the general population (P < 0.000). No significant difference occurred between the medication groups. A significant adjusted odds ratio of 2.79 (95% CI 1.286–6.049) was found for special care nursery and psychiatric admission during pregnancy but not for psychotropic medication. Conclusion: Rates of special care nursery admission are elevated in neonates of women with severe mental illness taking psychotropic medication, but were not different for monotherapy or polytherapy when prescribing antidepressants or antipsychotic medication. Additional vulnerability occurs in the neonates of women with a mental illness and paediatric presence at delivery is recommended. |
| first_indexed | 2025-11-14T09:57:07Z |
| format | Journal Article |
| id | curtin-20.500.11937-53940 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:57:07Z |
| publishDate | 2017 |
| publisher | Wiley-Blackwell Publishing Asia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-539402017-10-24T08:11:33Z The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness Frayne, J. Nguyen, T. Bennett, K. Allen, S. Hauck, Yvonne Liira, H. Background: Psychotropic medication use occurs in 8% of pregnancies, with rates increasing, and often multiple medications prescribed. Aims: This study aims to determine if the use of psychotropic medication, in a cohort of women with severe mental illness, increases rates of special care nursery admission and reports differences between antidepressant and antipsychotic medication use either alone or in combination. Methods: A retrospective database analysis from a cohort with severe mental illness in pregnancy identified 268 pregnant women who were grouped according to medication type. Demographic, obstetric and neonatal variables were analysed using t-tests, χ2, analysis of variance and logistic regression analysis for special care nursery admission. Results: The medication groups consisted of: women taking no psychotropic medications (n = 67); those taking antipsychotics (n = 87); those taking antidepressants (n = 55); those taking and a combination of antidepressants/antipsychotics (n = 59). Rates of special care nursery admission in women who took psychotropic medication (41.3%) were elevated compared to those who did not (26.9%) (P = 0.035), and were significantly raised when compared to the general population (P < 0.000). No significant difference occurred between the medication groups. A significant adjusted odds ratio of 2.79 (95% CI 1.286–6.049) was found for special care nursery and psychiatric admission during pregnancy but not for psychotropic medication. Conclusion: Rates of special care nursery admission are elevated in neonates of women with severe mental illness taking psychotropic medication, but were not different for monotherapy or polytherapy when prescribing antidepressants or antipsychotic medication. Additional vulnerability occurs in the neonates of women with a mental illness and paediatric presence at delivery is recommended. 2017 Journal Article http://hdl.handle.net/20.500.11937/53940 10.1111/ajo.12621 Wiley-Blackwell Publishing Asia restricted |
| spellingShingle | Frayne, J. Nguyen, T. Bennett, K. Allen, S. Hauck, Yvonne Liira, H. The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| title | The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| title_full | The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| title_fullStr | The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| title_full_unstemmed | The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| title_short | The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| title_sort | effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness |
| url | http://hdl.handle.net/20.500.11937/53940 |