The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the loss of glycemic control. Recent studies have shown significant inflammation and disturbed bile acid homeostasis, associated with T1DM. Bile acids are endogenously produced as a result of cholesterol catabolism in the live...
| Main Authors: | , |
|---|---|
| Format: | Journal Article |
| Published: |
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/53549 |
| _version_ | 1848759171016556544 |
|---|---|
| author | Woodhams, L. Al-Salami, Hani |
| author_facet | Woodhams, L. Al-Salami, Hani |
| author_sort | Woodhams, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the loss of glycemic control. Recent studies have shown significant inflammation and disturbed bile acid homeostasis, associated with T1DM. Bile acids are endogenously produced as a result of cholesterol catabolism in the liver and solely metabolized by gut microflora. This review investigates their potential oral delivery in T1DM using targeted delivery and encapsulation technologies. A sensitive and selective search was carried out using different search engines and databases. Keywords used included diabetes mellitus, bile acids and inflammation. To conclude, bile acids have a significant impact on diabetes symptoms and, when microencapsulated, may be used as an adjunct therapy to supplement T1DM treatment. |
| first_indexed | 2025-11-14T09:55:38Z |
| format | Journal Article |
| id | curtin-20.500.11937-53549 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:55:38Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-535492017-10-23T03:30:51Z The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus Woodhams, L. Al-Salami, Hani Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the loss of glycemic control. Recent studies have shown significant inflammation and disturbed bile acid homeostasis, associated with T1DM. Bile acids are endogenously produced as a result of cholesterol catabolism in the liver and solely metabolized by gut microflora. This review investigates their potential oral delivery in T1DM using targeted delivery and encapsulation technologies. A sensitive and selective search was carried out using different search engines and databases. Keywords used included diabetes mellitus, bile acids and inflammation. To conclude, bile acids have a significant impact on diabetes symptoms and, when microencapsulated, may be used as an adjunct therapy to supplement T1DM treatment. 2017 Journal Article http://hdl.handle.net/20.500.11937/53549 10.4155/tde-2017-0010 restricted |
| spellingShingle | Woodhams, L. Al-Salami, Hani The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus |
| title | The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus |
| title_full | The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus |
| title_fullStr | The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus |
| title_full_unstemmed | The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus |
| title_short | The roles of bile acids and applications of microencapsulation technology in treating Type 1 diabetes mellitus |
| title_sort | roles of bile acids and applications of microencapsulation technology in treating type 1 diabetes mellitus |
| url | http://hdl.handle.net/20.500.11937/53549 |