Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress
Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on ma...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/53525 |
| _version_ | 1848759165221076992 |
|---|---|
| author | Vieceli Dalla Sega, F. Aquila, G. Fortini, F. Vaccarezza, Mauro Secchiero, P. Rizzo, P. Campo, G. |
| author_facet | Vieceli Dalla Sega, F. Aquila, G. Fortini, F. Vaccarezza, Mauro Secchiero, P. Rizzo, P. Campo, G. |
| author_sort | Vieceli Dalla Sega, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting from-or promoting-the development of endothelial dysfunction. |
| first_indexed | 2025-11-14T09:55:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-53525 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:55:33Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-535252017-10-13T00:14:59Z Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress Vieceli Dalla Sega, F. Aquila, G. Fortini, F. Vaccarezza, Mauro Secchiero, P. Rizzo, P. Campo, G. Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting from-or promoting-the development of endothelial dysfunction. 2017 Journal Article http://hdl.handle.net/20.500.11937/53525 10.1002/biof.1359 restricted |
| spellingShingle | Vieceli Dalla Sega, F. Aquila, G. Fortini, F. Vaccarezza, Mauro Secchiero, P. Rizzo, P. Campo, G. Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress |
| title | Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress |
| title_full | Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress |
| title_fullStr | Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress |
| title_full_unstemmed | Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress |
| title_short | Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress |
| title_sort | context-dependent function of ros in the vascular endothelium: the role of the notch pathway and shear stress |
| url | http://hdl.handle.net/20.500.11937/53525 |