Role of NF-κB in tumorigenesis
Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor reg...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/53174 |
| _version_ | 1848759082529325056 |
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| author | Shanmugam, M. Kumar, Alan Prem Tan, B. Sethi, G. |
| author_facet | Shanmugam, M. Kumar, Alan Prem Tan, B. Sethi, G. |
| author_sort | Shanmugam, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer. |
| first_indexed | 2025-11-14T09:54:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-53174 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:54:14Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-531742017-10-12T06:06:19Z Role of NF-κB in tumorigenesis Shanmugam, M. Kumar, Alan Prem Tan, B. Sethi, G. Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer. 2013 Journal Article http://hdl.handle.net/20.500.11937/53174 10.1615/ForumImmunDisTher.2013008382 restricted |
| spellingShingle | Shanmugam, M. Kumar, Alan Prem Tan, B. Sethi, G. Role of NF-κB in tumorigenesis |
| title | Role of NF-κB in tumorigenesis |
| title_full | Role of NF-κB in tumorigenesis |
| title_fullStr | Role of NF-κB in tumorigenesis |
| title_full_unstemmed | Role of NF-κB in tumorigenesis |
| title_short | Role of NF-κB in tumorigenesis |
| title_sort | role of nf-κb in tumorigenesis |
| url | http://hdl.handle.net/20.500.11937/53174 |