Defining the Anti-Cancer Activity of Tricarbonyl Rhenium Complexes: Induction of G2/M Cell Cycle Arrest and Blockade of Aurora-A Kinase Phosphorylation

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Defining the Anti-Cancer Activity of Tricarbonyl Rhenium Complexes: Induction of G2/M Cell Cycle Arrest and Blockade of Aurora-A Kinase Phosphorylation

Rhenium and ruthenium complexes containing N-heterocylic carbene (NHC) ligands and conjugated to indomethacin were prepared. The anticancer properties were probed against pancreatic cell lines, revealing a remarkable activity of the rhenium fragment as anticancer agent. The ruthenium complexes were...

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Bibliographic Details
Main Authors:	Simpson, Peter, Casari, Ilaria, Paternoster, Silvano, Skelton, B., Falasca, Marco, Massi, Massimiliano
Format:	Journal Article
Published:	Wiley - V C H Verlag GmbH & Co. KGaA 2017
Online Access:	http://hdl.handle.net/20.500.11937/52825

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