Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1a (IL-1a) mRNA levels and secretion of IL-1a protein

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Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1a (IL-1a) mRNA levels and secretion of IL-1a protein

Alleles of IL1A-889(C>T) and IL1A+4845(G>T) are in linkage disequilibrium. Interleukin 1a (IL-1a) is produced as a precursor protein and cleaved at positions 117-118 by calpain, generating a mature protein for export. IL1A+4845 affects amino acids expressed at position 114 and hence ma...

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Bibliographic Details
Main Authors:	Lee, S., Temple, S., Roberts, S., Price, Patricia
Format:	Journal Article
Published:	Blackwell Munksgaard 2008
Online Access:	http://hdl.handle.net/20.500.11937/5236

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