Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide
Ulva fasciata belonging to the family Ulvaceae, commonly known as ‘sea lettuce’, is an abundantly growing green seaweed in coastal seashore of South China. Three different molecular weight sulfated polysaccharides (UFP1, UFP2 and UFP3) were extracted and separated from U. fasciata by hot water extra...
| Main Authors: | , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier BV
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/5234 |
| _version_ | 1848744739244867584 |
|---|---|
| author | Shao, Ping Pei, Yaping Fang, Zhongxiang Sun, Peilong |
| author_facet | Shao, Ping Pei, Yaping Fang, Zhongxiang Sun, Peilong |
| author_sort | Shao, Ping |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Ulva fasciata belonging to the family Ulvaceae, commonly known as ‘sea lettuce’, is an abundantly growing green seaweed in coastal seashore of South China. Three different molecular weight sulfated polysaccharides (UFP1, UFP2 and UFP3) were extracted and separated from U. fasciata by hot water extraction and ultrafiltration. The three native UFP fractions had partial desulfurization by solvolytic desulfation respectively and the effect of sulfate content on the exhibition of the antioxidant and anti-tumor capacities had been evaluated and compared. The results showed that each native polysaccharide (UFP1, UFP2, UFP3) with high sulfate content exhibited better antioxidant activities compared with the partial desulfated polysaccharides (DS-UFP1, DS-UFP2, DS-UFP3). Specifically, UFP2 with relatively high sulfate content, molecular weight and uronic acid content had consistently excellent antioxidant performances. However, UFP2 demonstrated the minimal inhibitory effects on growth of DLD intestinal cancer cells. Instead, DS-UFP3 with the lowest sulfate content but highest uronic acid content and molecular weight exhibited the best antitumor activity. |
| first_indexed | 2025-11-14T06:06:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-5234 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:06:15Z |
| publishDate | 2014 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-52342017-09-13T14:44:36Z Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide Shao, Ping Pei, Yaping Fang, Zhongxiang Sun, Peilong Ulva fasciata polysaccharides Partial desulfation Activitya Ulva fasciata belonging to the family Ulvaceae, commonly known as ‘sea lettuce’, is an abundantly growing green seaweed in coastal seashore of South China. Three different molecular weight sulfated polysaccharides (UFP1, UFP2 and UFP3) were extracted and separated from U. fasciata by hot water extraction and ultrafiltration. The three native UFP fractions had partial desulfurization by solvolytic desulfation respectively and the effect of sulfate content on the exhibition of the antioxidant and anti-tumor capacities had been evaluated and compared. The results showed that each native polysaccharide (UFP1, UFP2, UFP3) with high sulfate content exhibited better antioxidant activities compared with the partial desulfated polysaccharides (DS-UFP1, DS-UFP2, DS-UFP3). Specifically, UFP2 with relatively high sulfate content, molecular weight and uronic acid content had consistently excellent antioxidant performances. However, UFP2 demonstrated the minimal inhibitory effects on growth of DLD intestinal cancer cells. Instead, DS-UFP3 with the lowest sulfate content but highest uronic acid content and molecular weight exhibited the best antitumor activity. 2014 Journal Article http://hdl.handle.net/20.500.11937/5234 10.1016/j.ijbiomac.2014.01.043 Elsevier BV restricted |
| spellingShingle | Ulva fasciata polysaccharides Partial desulfation Activitya Shao, Ping Pei, Yaping Fang, Zhongxiang Sun, Peilong Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide |
| title | Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide |
| title_full | Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide |
| title_fullStr | Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide |
| title_full_unstemmed | Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide |
| title_short | Effects of Partial Desulfation on Antioxidant and Inhibition of DLD Cancer Cell of Ulva Fasciata Polysaccharide |
| title_sort | effects of partial desulfation on antioxidant and inhibition of dld cancer cell of ulva fasciata polysaccharide |
| topic | Ulva fasciata polysaccharides Partial desulfation Activitya |
| url | http://hdl.handle.net/20.500.11937/5234 |