Aging and cancer: The role of macrophages and neutrophils

QR Code

Aging and cancer: The role of macrophages and neutrophils

Impaired immune function has been implicated in the declining health and higher incidence of cancer in the elderly. However, age-related changes to immunity are not completely understood. Neutrophils and macrophages represent the first line of defence yet their ability to phagocytose pathogens decre...

Full description

Bibliographic Details
Main Authors:	Jackaman, Connie, Tomay, Federica, Duong, Lelinh, Abdol Razak, Norbaini Bintu, Pixley, F., Metharom, Pat, Nelson, Delia
Format:	Journal Article
Published:	2017
Online Access:	http://hdl.handle.net/20.500.11937/52250

Similar Items

Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?
by: Jackaman, Connie, et al.
Published: (2013)

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T- and B-cell zones
by: Tomay, F., et al.
Published: (2018)

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2014)

Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
by: Duong, L., et al.
Published: (2018)

Pancreatic cancer-induced neutrophil extracellular traps: A potential contributor to cancer-associated thrombosis
by: Razak, N., et al.
Published: (2017)

Understanding the underlying mechanisms behind macrophage dysfunction in the elderly tumour microenvironment
by: Duong, Lelinh
Published: (2023)

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones
by: Elaskalani, O., et al.
Published: (2018)

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
by: Jackaman, Connie, et al.
Published: (2013)

Sarcostemma viminale activates macrophages to a pro-inflammatory phenotype
by: Brestovac, Brian, et al.
Published: (2014)

Targeting macrophages rescues age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2016)

CD8+ cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy
by: Jackaman, Connie, et al.
Published: (2019)

Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules
by: Gardner, J., et al.
Published: (2017)

The interplay between Pseudomonas aeruginosa and human macrophages and neutrophils
by: Muntaka, Sirina
Published: (2017)

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy
by: Gardner, J., et al.
Published: (2018)

Extracellular DNA and histones are dispensable for neutrophil extracellular trap-induced aggregation of human washed platelets
by: Elaskalani, O., et al.
Published: (2018)

Mechanisms of Cancer-Associated Thrombosis: Role of Cancer-Derived Exosomes
by: Abdol Razak, Norbaini Binti
Published: (2024)

Murine mesothelioma induces locally-proliferating IL-10+TNF-a+CD206-CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy
by: Jackaman, Connie, et al.
Published: (2016)

Characterising murine hippocampal iron homeostasis, in relation to markers of brain inflammation and metabolism, during ageing
by: Ellison, Gae, et al.
Published: (2022)

Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responses
by: Jackaman, Connie, et al.
Published: (2012)

Intratumoral interleukin-2/agonist CD40 antibody drives CD4+-independent resolution of treated-tumors and CD4+-dependent systemic and memory responses
by: Jackaman, Connie, et al.
Published: (2012)

Role of inflammatory mediators, macrophages, and neutrophils in glioma maintenance and progression: mechanistic understanding and potential therapeutic applications
by: Basheer, Abdul Samad, et al.
Published: (2021)

Molecular and cellular mechanisms of chemoresistance in pancreatic cancer
by: Adamska, Aleksandra, et al.
Published: (2018)

Aging induces increased expression of checkpoint inhibitory molecules on dendritic cells
by: Gardner, J., et al.
Published: (2016)

CD40-activated B cells contribute to mesothelioma tumor regression
by: Jackaman, Connie, et al.
Published: (2011)

Physiological roles of macrophages
by: Gordon, Siamon, et al.
Published: (2017)

IL-2/CD40-driven NK cells install and maintain potency in the anti-mesothelioma effector/memory phase
by: Jackaman, Connie, et al.
Published: (2012)

Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment
by: Elahy, Mina, et al.
Published: (2015)

Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo
by: Jackaman, Connie, et al.
Published: (2012)

Rapid copper acquisition by developing murine mesothelioma: Decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration
by: Crowe, Andrew, et al.
Published: (2013)

The History of Armand Trousseau and Cancer-Associated Thrombosis
by: Metharom, Pat, et al.
Published: (2019)

The functional role of platelets in the regulation of angiogenesis
by: Walsh, T., et al.
Published: (2015)

Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function
by: Gardner, J., et al.
Published: (2015)

The role of platelet-derived ADP and ATP in promoting pancreatic cancer cell survival and gemcitabine resistance
by: Elaskalani, Omar, et al.
Published: (2017)

Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer
by: Elaskalani, O., et al.
Published: (2017)

Targeting platelets for the treatment of cancer
by: Elaskalani, Omar, et al.
Published: (2017)

Microparticles facilitate neutrophil platelet crosstalk
by: Andrews, R., et al.
Published: (2008)

Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice
by: Gardner, Joanne, et al.
Published: (2014)

Ageing and Mesothelioma Drive Lipid Accumulation and Dysfunction in Dendritic Cells and Macrophages
by: Sheeraz, Mohd
Published: (2022)

Cancer-associated thrombosis: An overview of mechanisms, risk factors, and treatment
by: Razak, N., et al.
Published: (2018)

Despite generating a weak tumour-specific CTL response during tumour progression chemotherapy is only effective in elderly mice if T cells are present
by: Nelson, D., et al.
Published: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1lhbs9sfrsda1qjc5ub2dhnrn2