Inversion-based propofol dosing for intravenous induction of hypnosis

© 2016 Elsevier B.V.In this paper we propose an inversion-based methodology for the computation of a feedforward action for the propofol intravenous administration during the induction of hypnosis in general anesthesia. In particular, the typical initial bolus is substituted with a command signal th...

Full description

Bibliographic Details
Main Authors: Padula, Fabrizio, Ionescu, C., Latronico, N., Paltenghi, M., Visioli, A., Vivacqua, G.
Format: Journal Article
Published: Elsevier 2016
Online Access:http://hdl.handle.net/20.500.11937/52197
Description
Summary:© 2016 Elsevier B.V.In this paper we propose an inversion-based methodology for the computation of a feedforward action for the propofol intravenous administration during the induction of hypnosis in general anesthesia. In particular, the typical initial bolus is substituted with a command signal that is obtained by predefining a desired output and by applying an input-output inversion procedure. The robustness of the method has been tested by considering a set of patients with different model parameters, which is representative of a large population.