Wnt signaling in triple-negative breast cancer
Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregula...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/52196 |
| _version_ | 1848758869368504320 |
|---|---|
| author | Pohl, S. Brook, N. Agostino, Mark Arfuso, Frank Kumar, Alan Prem Dharmarajan, Arunasalam |
| author_facet | Pohl, S. Brook, N. Agostino, Mark Arfuso, Frank Kumar, Alan Prem Dharmarajan, Arunasalam |
| author_sort | Pohl, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease. |
| first_indexed | 2025-11-14T09:50:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-52196 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:50:50Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-521962017-10-11T05:57:55Z Wnt signaling in triple-negative breast cancer Pohl, S. Brook, N. Agostino, Mark Arfuso, Frank Kumar, Alan Prem Dharmarajan, Arunasalam Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease. 2017 Journal Article http://hdl.handle.net/20.500.11937/52196 10.1038/oncsis.2017.14 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Pohl, S. Brook, N. Agostino, Mark Arfuso, Frank Kumar, Alan Prem Dharmarajan, Arunasalam Wnt signaling in triple-negative breast cancer |
| title | Wnt signaling in triple-negative breast cancer |
| title_full | Wnt signaling in triple-negative breast cancer |
| title_fullStr | Wnt signaling in triple-negative breast cancer |
| title_full_unstemmed | Wnt signaling in triple-negative breast cancer |
| title_short | Wnt signaling in triple-negative breast cancer |
| title_sort | wnt signaling in triple-negative breast cancer |
| url | http://hdl.handle.net/20.500.11937/52196 |