A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions
Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Wiley - V C H Verlag GmbH & Co. KGaA
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/52113 |
| _version_ | 1848758849622769664 |
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| author | Klenner, Mitchell Pascali, G. Zhang, B. Sia, T. Spare, L. Krause-Heuer, A. Aldrich-Wright, J. Greguric, I. Guastella, A. Massi, Massimiliano Fraser, B. |
| author_facet | Klenner, Mitchell Pascali, G. Zhang, B. Sia, T. Spare, L. Krause-Heuer, A. Aldrich-Wright, J. Greguric, I. Guastella, A. Massi, Massimiliano Fraser, B. |
| author_sort | Klenner, Mitchell |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes. |
| first_indexed | 2025-11-14T09:50:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-52113 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:50:32Z |
| publishDate | 2017 |
| publisher | Wiley - V C H Verlag GmbH & Co. KGaA |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-521132018-04-12T01:33:47Z A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions Klenner, Mitchell Pascali, G. Zhang, B. Sia, T. Spare, L. Krause-Heuer, A. Aldrich-Wright, J. Greguric, I. Guastella, A. Massi, Massimiliano Fraser, B. Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes. 2017 Journal Article http://hdl.handle.net/20.500.11937/52113 10.1002/chem.201700440 Wiley - V C H Verlag GmbH & Co. KGaA fulltext |
| spellingShingle | Klenner, Mitchell Pascali, G. Zhang, B. Sia, T. Spare, L. Krause-Heuer, A. Aldrich-Wright, J. Greguric, I. Guastella, A. Massi, Massimiliano Fraser, B. A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions |
| title | A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions |
| title_full | A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions |
| title_fullStr | A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions |
| title_full_unstemmed | A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions |
| title_short | A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions |
| title_sort | fluorine-18 radiolabeling method enabled by rhenium(i) complexation circumvents the requirement of anhydrous conditions |
| url | http://hdl.handle.net/20.500.11937/52113 |