Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model
This thesis embodies research that has demonstrated that there is strong case for further development of novel live attenuated metabolite deficient B pertussis vaccine such that it is non-toxic because it polarises the immune response of DTaP-vaccinated mice from Th2 to Th1 following booster vaccina...
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| Format: | Thesis |
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Curtin University
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/51705 |
| _version_ | 1848758787851157504 |
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| author | Alhashmi, Ibrahim |
| author_facet | Alhashmi, Ibrahim |
| author_sort | Alhashmi, Ibrahim |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis embodies research that has demonstrated that there is strong case for further development of novel live attenuated metabolite deficient B pertussis vaccine such that it is non-toxic because it polarises the immune response of DTaP-vaccinated mice from Th2 to Th1 following booster vaccination with the live attenuated vaccine thus offering the chance of long term protection against whooping cough and disrupting the transmission from adolescents and adults to infants. |
| first_indexed | 2025-11-14T09:49:33Z |
| format | Thesis |
| id | curtin-20.500.11937-51705 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:49:33Z |
| publishDate | 2012 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-517052017-04-19T04:16:41Z Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model Alhashmi, Ibrahim This thesis embodies research that has demonstrated that there is strong case for further development of novel live attenuated metabolite deficient B pertussis vaccine such that it is non-toxic because it polarises the immune response of DTaP-vaccinated mice from Th2 to Th1 following booster vaccination with the live attenuated vaccine thus offering the chance of long term protection against whooping cough and disrupting the transmission from adolescents and adults to infants. 2012 Thesis http://hdl.handle.net/20.500.11937/51705 Curtin University fulltext |
| spellingShingle | Alhashmi, Ibrahim Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model |
| title | Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model |
| title_full | Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model |
| title_fullStr | Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model |
| title_full_unstemmed | Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model |
| title_short | Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model |
| title_sort | live metabolite-deficient bordetella pertussis: determination of suitability for use as a vaccine in humans using the pertussis mouse model |
| url | http://hdl.handle.net/20.500.11937/51705 |