An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy
This thesis showed that specialised immune cells, dendritic cells and T cells, that play a key role in protecting us from cancer become increasingly dysfunctional (suppressive) during aging, which is exacerbated by cancer. Moreover, anti-cancer chemotherapy and immunotherapy promote even more suppre...
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| Format: | Thesis |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/51694 |
| _version_ | 1848758337283293184 |
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| author | Gardner, Joanne Karina |
| author_facet | Gardner, Joanne Karina |
| author_sort | Gardner, Joanne Karina |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis showed that specialised immune cells, dendritic cells and T cells, that play a key role in protecting us from cancer become increasingly dysfunctional (suppressive) during aging, which is exacerbated by cancer. Moreover, anti-cancer chemotherapy and immunotherapy promote even more suppressive dendritic cells and T cells, which may explain reduced treatment efficacy in the elderly. The data suggest that combining chemotherapy and/or immunotherapy with strategies to alleviate immunosuppression may improve elderly cancer patient outcomes. |
| first_indexed | 2025-11-14T09:42:23Z |
| format | Thesis |
| id | curtin-20.500.11937-51694 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:42:23Z |
| publishDate | 2016 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-516942017-03-28T03:40:23Z An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy Gardner, Joanne Karina This thesis showed that specialised immune cells, dendritic cells and T cells, that play a key role in protecting us from cancer become increasingly dysfunctional (suppressive) during aging, which is exacerbated by cancer. Moreover, anti-cancer chemotherapy and immunotherapy promote even more suppressive dendritic cells and T cells, which may explain reduced treatment efficacy in the elderly. The data suggest that combining chemotherapy and/or immunotherapy with strategies to alleviate immunosuppression may improve elderly cancer patient outcomes. 2016 Thesis http://hdl.handle.net/20.500.11937/51694 Curtin University fulltext |
| spellingShingle | Gardner, Joanne Karina An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| title | An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| title_full | An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| title_fullStr | An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| title_full_unstemmed | An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| title_short | An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| title_sort | increase in suppressive dendritic cells and t cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy |
| url | http://hdl.handle.net/20.500.11937/51694 |