NHE-1: A promising target for novel anti-cancer therapeutics

QR Code

NHE-1: A promising target for novel anti-cancer therapeutics

Among the many factors involved in the maintenance of homeostatic growth is the tight regulation of cellular pH. Intracellular pH of normal cells is maintained within a physiological range thanks to the activity of a number of pH regulators that respond to the acid-base shifts associated with normal...

Full description

Bibliographic Details
Main Authors:	Loo, S., Chang, M., Chua, C., Kumar, A., Pervaiz, Shazib, Clement, M.
Format:	Journal Article
Published:	2012
Online Access:	http://hdl.handle.net/20.500.11937/51282

Similar Items

Na+/H+ exchanger 1 (NHE-1) redox-regulated gene and intracellular target for the redox control of cell death sensitivity
by: Akram, S., et al.
Published: (2011)

PPARγ disease gene network and identification of therapeutic targets for prostate cancer
by: Venkatachalam, G., et al.
Published: (2011)

Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma
by: Prem Kumar, Alan, et al.
Published: (2013)

Novel therapeutic targets in rheumatoid arthritis
by: Sakthiswary Rajalingham,
Published: (2018)

A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma
by: Maillet, A., et al.
Published: (2013)

Breast Cancer: A Molecular and Redox Snapshot
by: Raman, D., et al.
Published: (2016)

Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer
by: Alcantara, M., et al.
Published: (2013)

Breast cancer bone metastases: pathogenesis and therapeutic targets
by: Brook, Naomi, et al.
Published: (2018)

Therapeutic potential of gambogic acid, a caged xanthone, to target cancer
by: Banik, K., et al.
Published: (2018)

Molecular targets and anti-cancer potential of escin
by: Cheong, D., et al.
Published: (2018)

The role of membrane transporters (NHE-1 and AE-2) in secondary bone healing of tibia-fractured Sprague-Dawley rats
by: Handool, Kareem Obayes
Published: (2017)

C-Abl inhibition; a novel therapeutic target for Parkinson’s disease
by: Abushouk, Abdelrahman Ibrahim, et al.
Published: (2018)

Therapeutic targeting of the leukaemia microenvironment
by: Kuek, V., et al.
Published: (2021)

gRASping the redox lever to modulate cancer cell fate signaling
by: Foo, C., et al.
Published: (2019)

Targeting PDK1 in cancer
by: Raimondi, C., et al.
Published: (2011)

The anti-oxidant and pro-oxidant dichotomy of Bcl-2.
by: Yee, Y., et al.
Published: (2016)

Role of calpain in breast cancer and regulation of therapeutic response to targeted treatment
by: Pu, Xuan
Published: (2016)

IDENTIFYING A NOVEL THERAPEUTIC STRATEGY FOR ASTHMA: TARGETING AIRWAY EPITHELIAL CELL RESTITUTION
by: Iosifidis, T., et al.
Published: (2017)

Targeting tumour-astrocyte crosstalk for rational identification of novel therapeutic targets for atypical Teratoid/ Rhabdoid tumours
by: Porter, Harry
Published: (2025)

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity
by: Velaithan, R., et al.
Published: (2011)

Cancer and apoptosis: the apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics
by: Chaudhry, Gul-e-Saba, et al.
Published: (2022)

Winding back Wnt signalling: Potential therapeutic targets for treating gastric cancers
by: Flanagan, D., et al.
Published: (2017)

Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer
by: Elaskalani, O., et al.
Published: (2017)

Application of Proteomics Approaches in the Identification of New Markers and Therapeutic Targets for Breast Cancer
by: Moh’d Hamadneh, Lama Abdel Qader
Published: (2008)

Development and evaluation of selective nitroxanthone derivatives: a promising compound for targeting MCF-7 breast cancer cells
by: Devakrishnan, Pavithren, et al.
Published: (2025)

On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry
by: Pang, Vincent, et al.
Published: (2012)

Roles of sodium hydrogen exchanger (NHE1) and anion exchanger (AE2) across chondrocytes plasma membrane during longitudinal bone growth
by: Abdul Abubakar, Adamu, et al.
Published: (2022)

Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives
by: Morshed, A. K.M.Helal, et al.
Published: (2023)

Amino acid transporters in breast cancer: promising prognostic markers and emerging targets across molecular subtypes
by: El Ansari, Rokaya
Published: (2020)

Hippo circuitry and the redox modulation of hippo components in cancer cell fate decisions
by: Ashraf, A., et al.
Published: (2015)

Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target
by: Mussai, Francis, et al.
Published: (2015)

Cancer chemoprevention by nuts: Evidence and promises
by: Falasca, Marco, et al.
Published: (2012)

New therapeutic targets for osteoarthritis pain
by: Walsh, David A., et al.
Published: (2017)

Repressing the activity of protein kinase CK2 releases the brakes on mitochondria-mediated apoptosis in cancer cells
by: Hanif, I., et al.
Published: (2011)

Redox regulation of cancer cell migration and invasion
by: Tochhawng, L., et al.
Published: (2013)

The anti- cancer effect of clinacanthus nutans in 4T1 breast cancer in balb/c mice
by: Chua, Sik Juan
Published: (2015)

Evaluation of anti-nNav1.5 antibodies as potential therapeutic agent in suppressing breast cancer invasion and metastasis
by: Sharudin, Nur Aishah
Published: (2022)

MPTP-induced mouse model of Parkinson’s disease: a promising direction for therapeutic strategies
by: Mustapha, Musa, et al.
Published: (2021)

Citrullinated α-enolase is an effective target for anti-cancer immunity
by: Cook, Katherine, et al.
Published: (2018)