Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy
© 2016 Elsevier B.V.A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produ...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Elsevier BV
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/51281 |
| _version_ | 1848758658994798592 |
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| author | Patel, Kunal Raj, B. Chen, Yan Lou, Xia |
| author_facet | Patel, Kunal Raj, B. Chen, Yan Lou, Xia |
| author_sort | Patel, Kunal |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016 Elsevier B.V.A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produced nano-PSs, due to the charge recombination via electron trapping by dissolved Fe3+. A time and dose dependant toxicity associated with the nano-PSs was observed upon exposure to human epithelial colorectal adenocarcinoma (Caco-2) cells in the dark. UV irradiation of the synthesised nano-PSs resulted in a significant photo-killing effect with drastic reduction in Caco-2 cell viability to as low as 6%. Reduction in viability upon exposure was due fundamentally to cellular interactions with light irradiated PSs as the influence of radiation alone was subtracted. FA conjugation further enhanced the photo-killing effect. |
| first_indexed | 2025-11-14T09:47:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-51281 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:47:30Z |
| publishDate | 2017 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-512812023-08-02T06:39:08Z Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy Patel, Kunal Raj, B. Chen, Yan Lou, Xia © 2016 Elsevier B.V.A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produced nano-PSs, due to the charge recombination via electron trapping by dissolved Fe3+. A time and dose dependant toxicity associated with the nano-PSs was observed upon exposure to human epithelial colorectal adenocarcinoma (Caco-2) cells in the dark. UV irradiation of the synthesised nano-PSs resulted in a significant photo-killing effect with drastic reduction in Caco-2 cell viability to as low as 6%. Reduction in viability upon exposure was due fundamentally to cellular interactions with light irradiated PSs as the influence of radiation alone was subtracted. FA conjugation further enhanced the photo-killing effect. 2017 Journal Article http://hdl.handle.net/20.500.11937/51281 10.1016/j.colsurfb.2016.10.045 Elsevier BV restricted |
| spellingShingle | Patel, Kunal Raj, B. Chen, Yan Lou, Xia Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy |
| title | Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy |
| title_full | Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy |
| title_fullStr | Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy |
| title_full_unstemmed | Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy |
| title_short | Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy |
| title_sort | novel folic acid conjugated fe3o4-zno hybrid nanoparticles for targeted photodynamic therapy |
| url | http://hdl.handle.net/20.500.11937/51281 |