Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic...
| Main Authors: | , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier
2011
|
| Online Access: | http://hdl.handle.net/20.500.11937/51262 |
| _version_ | 1848758654371627008 |
|---|---|
| author | Indran, I. Tufo, G. Pervaiz, Shazib Brenner, C. |
| author_facet | Indran, I. Tufo, G. Pervaiz, Shazib Brenner, C. |
| author_sort | Indran, I. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells. This article is part of a Special Issue entitled: Bioenergetics of Cancer. © 2011 Published by Elsevier B.V. |
| first_indexed | 2025-11-14T09:47:25Z |
| format | Journal Article |
| id | curtin-20.500.11937-51262 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:47:25Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-512622017-09-13T15:34:26Z Recent advances in apoptosis, mitochondria and drug resistance in cancer cells Indran, I. Tufo, G. Pervaiz, Shazib Brenner, C. Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells. This article is part of a Special Issue entitled: Bioenergetics of Cancer. © 2011 Published by Elsevier B.V. 2011 Journal Article http://hdl.handle.net/20.500.11937/51262 10.1016/j.bbabio.2011.03.010 Elsevier unknown |
| spellingShingle | Indran, I. Tufo, G. Pervaiz, Shazib Brenner, C. Recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| title | Recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| title_full | Recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| title_fullStr | Recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| title_full_unstemmed | Recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| title_short | Recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| title_sort | recent advances in apoptosis, mitochondria and drug resistance in cancer cells |
| url | http://hdl.handle.net/20.500.11937/51262 |