Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway.

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway.

Vasculopathy is a major complication of diabetes. Impaired mitochondrial bioenergetics and biogenesis due to oxidative stress are a critical causal factor for diabetic endothelial dysfunction. Sirt1, an NAD(+)-dependent enzyme, is known to play an important protective role through deacetylation of m...

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Bibliographic Details
Main Authors: Yuan, Y., Shi, M., Li, L., Liu, J., Chen, B., Chen, Y., An, X., Liu, S., Luo, R., Long, D., Zhang, W., Newsholme, Philip, Cheng, J., Lu, Y.
Format: Journal Article
Published: 2016
Online Access:http://hdl.handle.net/20.500.11937/51215

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