Mitochondria: Redox metabolism and dysfunction
Mitochondria are the main intracellular location for fuel generation; however, they are not just power plants but involved in a range of other intracellular functions including regulation of redox homeostasis and cell fate. Dysfunction of mitochondria will result in oxidative stress which is one of...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/51151 |
| _version_ | 1848758627911860224 |
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| author | Kang, J. Pervaiz, Shazib |
| author_facet | Kang, J. Pervaiz, Shazib |
| author_sort | Kang, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Mitochondria are the main intracellular location for fuel generation; however, they are not just power plants but involved in a range of other intracellular functions including regulation of redox homeostasis and cell fate. Dysfunction of mitochondria will result in oxidative stress which is one of the underlying causal factors for a variety of diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, and cancer. In this paper, generation of reactive oxygen/nitrogen species (ROS/RNS) in the mitochondria, redox regulatory roles of certain mitochondrial proteins, and the impact on cell fate will be discussed. The current state of our understanding in mitochondrial dysfunction in pathological states and how we could target them for therapeutic purpose will also be briefly reviewed. © Copyright 2012 Jia Kang and Shazib Pervaiz. |
| first_indexed | 2025-11-14T09:47:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-51151 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:47:00Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-511512017-09-13T15:34:50Z Mitochondria: Redox metabolism and dysfunction Kang, J. Pervaiz, Shazib Mitochondria are the main intracellular location for fuel generation; however, they are not just power plants but involved in a range of other intracellular functions including regulation of redox homeostasis and cell fate. Dysfunction of mitochondria will result in oxidative stress which is one of the underlying causal factors for a variety of diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, and cancer. In this paper, generation of reactive oxygen/nitrogen species (ROS/RNS) in the mitochondria, redox regulatory roles of certain mitochondrial proteins, and the impact on cell fate will be discussed. The current state of our understanding in mitochondrial dysfunction in pathological states and how we could target them for therapeutic purpose will also be briefly reviewed. © Copyright 2012 Jia Kang and Shazib Pervaiz. 2012 Journal Article http://hdl.handle.net/20.500.11937/51151 10.1155/2012/896751 unknown |
| spellingShingle | Kang, J. Pervaiz, Shazib Mitochondria: Redox metabolism and dysfunction |
| title | Mitochondria: Redox metabolism and dysfunction |
| title_full | Mitochondria: Redox metabolism and dysfunction |
| title_fullStr | Mitochondria: Redox metabolism and dysfunction |
| title_full_unstemmed | Mitochondria: Redox metabolism and dysfunction |
| title_short | Mitochondria: Redox metabolism and dysfunction |
| title_sort | mitochondria: redox metabolism and dysfunction |
| url | http://hdl.handle.net/20.500.11937/51151 |