Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome
Advanced female age correlates with reduced ovarian reserve (OR) and is the primary factor underlying the limitation of success rates in Assisted Reproductive Technology (ART). Currently, predicted ovarian response to gonadotrophin stimulation is determined using transvaginal ultrasound to measure a...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/51138 |
| _version_ | 1848758624909787136 |
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| author | Keane, Kevin Cruzat, Vinicius Wagle, S. Chaudhary, N. Newsholme, Philip Yovich, John |
| author_facet | Keane, Kevin Cruzat, Vinicius Wagle, S. Chaudhary, N. Newsholme, Philip Yovich, John |
| author_sort | Keane, Kevin |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Advanced female age correlates with reduced ovarian reserve (OR) and is the primary factor underlying the limitation of success rates in Assisted Reproductive Technology (ART). Currently, predicted ovarian response to gonadotrophin stimulation is determined using transvaginal ultrasound to measure antral follicle count (AFC), an indirect measure of OR. However, assessing the level of anti-Mullerian hormone (AMH) has more recently been shown to correlate with OR, and its application has been adopted widely. This retrospective study was designed to determine the relationship between novel ranges of AMH and AFC in patients undergoing ART. There was a positive correlation between AMH and AFC category (r = 0.458, P < 0.01), with an 87% linear concordance observed for specific AFC ranges and mean serum AMH levels. Both OR markers were inversely correlated with female age (r = -0.428 and r = -0.392, respectively). Pregnancy and live birth rates were influenced by both AMH (P < 0.05) and AFC categories (P < 0.05). Conversely, miscarriage rates appeared to be more dependent on AFC categories (P < 0.05), but even more reliant on female age. Finally, the number of oocytes collected was positively correlated with AMH and AFC grading, while oocyte and embryo utilization rates were negatively correlated. Overall, both OR markers were positively and strongly related with each other, and when individual AMH readings were categorised into specific novel ranges, they demonstrated a more robust correlation with AFC groupings. Taken together, applying patient AMH within specific ranges may lead to a better estimation of OR and IVF outcomes. |
| first_indexed | 2025-11-14T09:46:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-51138 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:46:57Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-511382017-09-13T15:36:41Z Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome Keane, Kevin Cruzat, Vinicius Wagle, S. Chaudhary, N. Newsholme, Philip Yovich, John Advanced female age correlates with reduced ovarian reserve (OR) and is the primary factor underlying the limitation of success rates in Assisted Reproductive Technology (ART). Currently, predicted ovarian response to gonadotrophin stimulation is determined using transvaginal ultrasound to measure antral follicle count (AFC), an indirect measure of OR. However, assessing the level of anti-Mullerian hormone (AMH) has more recently been shown to correlate with OR, and its application has been adopted widely. This retrospective study was designed to determine the relationship between novel ranges of AMH and AFC in patients undergoing ART. There was a positive correlation between AMH and AFC category (r = 0.458, P < 0.01), with an 87% linear concordance observed for specific AFC ranges and mean serum AMH levels. Both OR markers were inversely correlated with female age (r = -0.428 and r = -0.392, respectively). Pregnancy and live birth rates were influenced by both AMH (P < 0.05) and AFC categories (P < 0.05). Conversely, miscarriage rates appeared to be more dependent on AFC categories (P < 0.05), but even more reliant on female age. Finally, the number of oocytes collected was positively correlated with AMH and AFC grading, while oocyte and embryo utilization rates were negatively correlated. Overall, both OR markers were positively and strongly related with each other, and when individual AMH readings were categorised into specific novel ranges, they demonstrated a more robust correlation with AFC groupings. Taken together, applying patient AMH within specific ranges may lead to a better estimation of OR and IVF outcomes. 2016 Journal Article http://hdl.handle.net/20.500.11937/51138 10.1016/j.repbio.2016.12.002 restricted |
| spellingShingle | Keane, Kevin Cruzat, Vinicius Wagle, S. Chaudhary, N. Newsholme, Philip Yovich, John Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome |
| title | Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome |
| title_full | Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome |
| title_fullStr | Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome |
| title_full_unstemmed | Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome |
| title_short | Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome |
| title_sort | specific ranges of anti-mullerian hormone and antral follicle count correlate to provide a prognostic indicator for ivf outcome |
| url | http://hdl.handle.net/20.500.11937/51138 |