Projections from the oral pontine reticular nucleus to the spinal cord of the mouse
The present study investigated projections of the mouse oral pontine reticular nucleus (PnO) to the spinal cord by (a) injecting a retrograde tracer fluoro-gold (FG) to the lumbar cord and (b) an anterograde tracer biotinylated dextran amine (BDA) to PnO. We found that PnO projects to the entire spi...
| Main Authors: | , , |
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| Format: | Journal Article |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/5109 |
| _version_ | 1848744704449970176 |
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| author | Huazheng, L. Watson, Charles Paxinos, G. |
| author_facet | Huazheng, L. Watson, Charles Paxinos, G. |
| author_sort | Huazheng, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The present study investigated projections of the mouse oral pontine reticular nucleus (PnO) to the spinal cord by (a) injecting a retrograde tracer fluoro-gold (FG) to the lumbar cord and (b) an anterograde tracer biotinylated dextran amine (BDA) to PnO. We found that PnO projects to the entire spinal cord with an ipsilateral predominance. PnO fibers mainly travel in the ipsilateral ventral funiculus in the entire cord, terminating in laminae 7–10 with a lower density of fibers and boutons in lower segments. A small number of fibers travel in the contralateral ventral funiculus in the cervical cord with a similar terminating pattern to the ipsilateral counterpart. The present study is the first demonstration of PnO fiber terminals in the mouse spinal cord. This pathway might be responsible for muscle atonia during REM sleep, but needs physiological research to confirm this. |
| first_indexed | 2025-11-14T06:05:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-5109 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:05:42Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-51092017-09-13T16:06:09Z Projections from the oral pontine reticular nucleus to the spinal cord of the mouse Huazheng, L. Watson, Charles Paxinos, G. The present study investigated projections of the mouse oral pontine reticular nucleus (PnO) to the spinal cord by (a) injecting a retrograde tracer fluoro-gold (FG) to the lumbar cord and (b) an anterograde tracer biotinylated dextran amine (BDA) to PnO. We found that PnO projects to the entire spinal cord with an ipsilateral predominance. PnO fibers mainly travel in the ipsilateral ventral funiculus in the entire cord, terminating in laminae 7–10 with a lower density of fibers and boutons in lower segments. A small number of fibers travel in the contralateral ventral funiculus in the cervical cord with a similar terminating pattern to the ipsilateral counterpart. The present study is the first demonstration of PnO fiber terminals in the mouse spinal cord. This pathway might be responsible for muscle atonia during REM sleep, but needs physiological research to confirm this. 2015 Journal Article http://hdl.handle.net/20.500.11937/5109 10.1016/j.neulet.2014.10.025 Elsevier restricted |
| spellingShingle | Huazheng, L. Watson, Charles Paxinos, G. Projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| title | Projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| title_full | Projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| title_fullStr | Projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| title_full_unstemmed | Projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| title_short | Projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| title_sort | projections from the oral pontine reticular nucleus to the spinal cord of the mouse |
| url | http://hdl.handle.net/20.500.11937/5109 |