Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?
Cell fate regulation is a function of diverse cell signaling pathways that promote cell survival and or inhibit cell death execution. In this regard, the role of the Bcl-2 family in maintaining a tight balance between cell death and cell proliferation has been extensively studied. The conventional d...
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| Format: | Journal Article |
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Frontiers Research Foundation
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/51001 |
| _version_ | 1848758588912173056 |
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| author | Kang, J. Pervaiz, Shazib |
| author_facet | Kang, J. Pervaiz, Shazib |
| author_sort | Kang, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Cell fate regulation is a function of diverse cell signaling pathways that promote cell survival and or inhibit cell death execution. In this regard, the role of the Bcl-2 family in maintaining a tight balance between cell death and cell proliferation has been extensively studied. The conventional dogma links cell fate regulation by the Bcl-2 family to its effect on mitochondrial permeabilization and apoptosis amplification. However, recent evidence provide a novel mechanism for death regulation by the Bcl-2 family via modulating cellular redox metabolism. For example overexpression of Bcl-2 has been shown to contribute to a pro-oxidant intracellular milieu and down-regulation of cellular superoxide levels enhanced death sensitivity of Bcl-2 overexpressing cells. Interestingly, gene knockdown of the small GTPase Rac1 or pharmacological inhibition of its activity also reverted death phenotype in Bcl-2 expressing cells. This appears to be a function of an interaction between Bcl-2 and Rac1. Similar functional associations have been described between the Bcl-2 family and other members of the Ras superfamily. These interactions at the mitochondria provide novel opportunities for strategic therapeutic targeting of drug-resistant cancers. © 2013 Kang and Pervaiz. |
| first_indexed | 2025-11-14T09:46:23Z |
| format | Journal Article |
| id | curtin-20.500.11937-51001 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:46:23Z |
| publishDate | 2013 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-510012017-09-13T15:35:12Z Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? Kang, J. Pervaiz, Shazib Cell fate regulation is a function of diverse cell signaling pathways that promote cell survival and or inhibit cell death execution. In this regard, the role of the Bcl-2 family in maintaining a tight balance between cell death and cell proliferation has been extensively studied. The conventional dogma links cell fate regulation by the Bcl-2 family to its effect on mitochondrial permeabilization and apoptosis amplification. However, recent evidence provide a novel mechanism for death regulation by the Bcl-2 family via modulating cellular redox metabolism. For example overexpression of Bcl-2 has been shown to contribute to a pro-oxidant intracellular milieu and down-regulation of cellular superoxide levels enhanced death sensitivity of Bcl-2 overexpressing cells. Interestingly, gene knockdown of the small GTPase Rac1 or pharmacological inhibition of its activity also reverted death phenotype in Bcl-2 expressing cells. This appears to be a function of an interaction between Bcl-2 and Rac1. Similar functional associations have been described between the Bcl-2 family and other members of the Ras superfamily. These interactions at the mitochondria provide novel opportunities for strategic therapeutic targeting of drug-resistant cancers. © 2013 Kang and Pervaiz. 2013 Journal Article http://hdl.handle.net/20.500.11937/51001 10.3389/fonc.2012.00206 Frontiers Research Foundation unknown |
| spellingShingle | Kang, J. Pervaiz, Shazib Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| title | Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| title_full | Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| title_fullStr | Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| title_full_unstemmed | Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| title_short | Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| title_sort | crosstalk between bcl-2 family and ras family small gtpases: potential cell fate regulation? |
| url | http://hdl.handle.net/20.500.11937/51001 |