Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27

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Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27

The small chaperone protein Hsp27 confers resistance to apoptosis, and therefore is an attractive anticancer drug target. We report here a novel mechanism underlying the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity of the small molecule LY303511, an inactive a...

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Bibliographic Details
Main Authors:	Mellier, G., Liu, D., Bellot, G., Lisa Holme, A., Pervaiz, Shazib
Format:	Journal Article
Published:	Nature Publishing Group 2013
Online Access:	http://hdl.handle.net/20.500.11937/50960

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