The anti-oxidant and pro-oxidant dichotomy of Bcl-2.
Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its conventional activity of titrating the pro-apoptotic effects...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/50917 |
| _version_ | 1848758567721500672 |
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| author | Yee, Y. Chong, S. Pervaiz, Shazib |
| author_facet | Yee, Y. Chong, S. Pervaiz, Shazib |
| author_sort | Yee, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its conventional activity of titrating the pro-apoptotic effects of proteins such as Bax and Bak at the mitochondria, also impacts cell fate decisions via modulating cellular redox metabolism. In this regard, both pro- and anti-oxidant effects of Bcl-2 overexpression have been described under different conditions and cellular contexts. In this short review, we attempt to analyze existing observations and present a probable explanation for the seemingly conflicting redox regulating activity of Bcl-2 from the standpoint of its pro-survival function. The consequential effect(s) of the dual redox functions of Bcl-2 are also discussed, particularly from the viewpoint of developing novel therapeutic strategies against cancers rendered refractory due to the aberrant expression of Bcl-2. |
| first_indexed | 2025-11-14T09:46:03Z |
| format | Journal Article |
| id | curtin-20.500.11937-50917 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:46:03Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-509172017-09-13T15:34:25Z The anti-oxidant and pro-oxidant dichotomy of Bcl-2. Yee, Y. Chong, S. Pervaiz, Shazib Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its conventional activity of titrating the pro-apoptotic effects of proteins such as Bax and Bak at the mitochondria, also impacts cell fate decisions via modulating cellular redox metabolism. In this regard, both pro- and anti-oxidant effects of Bcl-2 overexpression have been described under different conditions and cellular contexts. In this short review, we attempt to analyze existing observations and present a probable explanation for the seemingly conflicting redox regulating activity of Bcl-2 from the standpoint of its pro-survival function. The consequential effect(s) of the dual redox functions of Bcl-2 are also discussed, particularly from the viewpoint of developing novel therapeutic strategies against cancers rendered refractory due to the aberrant expression of Bcl-2. 2016 Journal Article http://hdl.handle.net/20.500.11937/50917 10.1515/hsz-2016-0127 restricted |
| spellingShingle | Yee, Y. Chong, S. Pervaiz, Shazib The anti-oxidant and pro-oxidant dichotomy of Bcl-2. |
| title | The anti-oxidant and pro-oxidant dichotomy of Bcl-2. |
| title_full | The anti-oxidant and pro-oxidant dichotomy of Bcl-2. |
| title_fullStr | The anti-oxidant and pro-oxidant dichotomy of Bcl-2. |
| title_full_unstemmed | The anti-oxidant and pro-oxidant dichotomy of Bcl-2. |
| title_short | The anti-oxidant and pro-oxidant dichotomy of Bcl-2. |
| title_sort | anti-oxidant and pro-oxidant dichotomy of bcl-2. |
| url | http://hdl.handle.net/20.500.11937/50917 |