The chaperone balance hypothesis: The importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management

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The chaperone balance hypothesis: The importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management

Recent evidence shows divergence between the concentrations of extracellular 70 kDa heat shock protein [eHSP70] and its intracellular concentrations [iHSP70] in people with type 2 diabetes (T2DM). A vital aspect regarding HSP70 physiology is its versatility to induce antagonistic actions, depending...

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Bibliographic Details
Main Authors:	Krause, M., Heck, T., Bittencourt, A., Scomazzon, S., Newsholme, Philip, Curi, R., Homem De Bittencourt, P.
Format:	Journal Article
Published:	Hindawi Publishing Corporation 2015
Online Access:	http://hdl.handle.net/20.500.11937/5082

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