Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

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Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

The human voltage-gated sodium channel sub-type 1.7 (hNaV1.7) is emerging as an attractive target for the development of potent and sub-type selective novel analgesics with increased potency and fewer side effects than existing therapeutics. HwTx-IV, a spider derived peptide toxin, inhibits hNaV1.7...

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Bibliographic Details
Main Authors:	Agwa, A., Lawrence, N., Deplazes, Evelyne, Cheneval, O., Chen, R., Craik, D., Schroeder, C., Henriques, S.
Format:	Journal Article
Published:	Elsevier 2017
Online Access:	http://hdl.handle.net/20.500.11937/50471

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