Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma
Background: Survival with the epithelioid subtype of malignant mesothelioma (MM) is longer than the biphasic or sarcomatoid subtypes. There is concern that cytology-diagnosed epithelioid MM may underdiagnose the biphasic subtype. This study examines survival differences between patients with epithel...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/50395 |
| _version_ | 1848758465071153152 |
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| author | Muruganandan, S. Alfonso, Helman Franklin, P. Shilkin, K. Segal, A. Olsen, N. Reid, Alison de Klerk, N. Musk, A. Brims, F. |
| author_facet | Muruganandan, S. Alfonso, Helman Franklin, P. Shilkin, K. Segal, A. Olsen, N. Reid, Alison de Klerk, N. Musk, A. Brims, F. |
| author_sort | Muruganandan, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Survival with the epithelioid subtype of malignant mesothelioma (MM) is longer than the biphasic or sarcomatoid subtypes. There is concern that cytology-diagnosed epithelioid MM may underdiagnose the biphasic subtype. This study examines survival differences between patients with epithelioid MM diagnosed by cytology only and other subtypes diagnosed by histology. Methods: Demographics, diagnosis method, MM subtype and survival were extracted from the Western Australia (WA) Mesothelioma Registry, which records details of all MM cases occurring in WA. Results: A total of 2024 MM cases were identified over 42 years. One thousand seven hundred forty-four (86.2%) were male, median (IQR) age was 68.6 (60.4–77.0) years. A total of 1212 (59.9%) cases were identified as epithelioid subtype of which 499 (41.2%) were diagnosed using fluid cytology only. Those with a cytology-only diagnosis were older than the histology group (median 70.2 vs 67.6 years, P<0.001), but median survival was similar (cytology 10.6 (5.5–19.2) vs histology 11.1 (4.8–19.8) months, P=0.727) and Cox regression modelling adjusting for age, sex, site and time since first exposure showed no difference in survival between the different diagnostic approaches. Conclusions: Survival of cytologically and histologically diagnosed epithelioid MM cases does not differ. A diagnostic tap should be considered adequate to diagnose epithelioid MM without need for further invasive testing. |
| first_indexed | 2025-11-14T09:44:25Z |
| format | Journal Article |
| id | curtin-20.500.11937-50395 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:44:25Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-503952017-09-13T15:48:50Z Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma Muruganandan, S. Alfonso, Helman Franklin, P. Shilkin, K. Segal, A. Olsen, N. Reid, Alison de Klerk, N. Musk, A. Brims, F. Background: Survival with the epithelioid subtype of malignant mesothelioma (MM) is longer than the biphasic or sarcomatoid subtypes. There is concern that cytology-diagnosed epithelioid MM may underdiagnose the biphasic subtype. This study examines survival differences between patients with epithelioid MM diagnosed by cytology only and other subtypes diagnosed by histology. Methods: Demographics, diagnosis method, MM subtype and survival were extracted from the Western Australia (WA) Mesothelioma Registry, which records details of all MM cases occurring in WA. Results: A total of 2024 MM cases were identified over 42 years. One thousand seven hundred forty-four (86.2%) were male, median (IQR) age was 68.6 (60.4–77.0) years. A total of 1212 (59.9%) cases were identified as epithelioid subtype of which 499 (41.2%) were diagnosed using fluid cytology only. Those with a cytology-only diagnosis were older than the histology group (median 70.2 vs 67.6 years, P<0.001), but median survival was similar (cytology 10.6 (5.5–19.2) vs histology 11.1 (4.8–19.8) months, P=0.727) and Cox regression modelling adjusting for age, sex, site and time since first exposure showed no difference in survival between the different diagnostic approaches. Conclusions: Survival of cytologically and histologically diagnosed epithelioid MM cases does not differ. A diagnostic tap should be considered adequate to diagnose epithelioid MM without need for further invasive testing. 2017 Journal Article http://hdl.handle.net/20.500.11937/50395 10.1038/bjc.2017.20 http://creativecommons.org/licenses/by-nc-sa/4.0/ Nature Publishing Group fulltext |
| spellingShingle | Muruganandan, S. Alfonso, Helman Franklin, P. Shilkin, K. Segal, A. Olsen, N. Reid, Alison de Klerk, N. Musk, A. Brims, F. Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| title | Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| title_full | Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| title_fullStr | Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| title_full_unstemmed | Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| title_short | Comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| title_sort | comparison of outcomes following a cytological or histological diagnosis of malignant mesothelioma |
| url | http://hdl.handle.net/20.500.11937/50395 |