Codon optimization underpins generalist parasitism in fungi
The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/50320 |
| _version_ | 1848758447001042944 |
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| author | Badet, T. Peyraud, R. Mbengue, M. Navaud, O. Derbyshire, Mark Oliver, Richard Barbacci, A. Raffaele, S. |
| author_facet | Badet, T. Peyraud, R. Mbengue, M. Navaud, O. Derbyshire, Mark Oliver, Richard Barbacci, A. Raffaele, S. |
| author_sort | Badet, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We found that the longer proteins encoded by broad host range fungi likely increase natural selection on codon optimization in these species. Accordingly, codon optimization correlates with host range across the fungal kingdom. At the species level, biased patterns of synonymous substitutions underpin increased codon optimization in a generalist but not a specialist fungal pathogen. Virulence genes were consistently enriched in highly codon-optimized genes of generalist but not specialist species. We conclude that codon optimization is related to the capacity of parasites to colonize multiple hosts. Our results link genome evolution and translational regulation to the long-term persistence of generalist parasitism. |
| first_indexed | 2025-11-14T09:44:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-50320 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:44:08Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-503202017-09-13T15:42:02Z Codon optimization underpins generalist parasitism in fungi Badet, T. Peyraud, R. Mbengue, M. Navaud, O. Derbyshire, Mark Oliver, Richard Barbacci, A. Raffaele, S. The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We found that the longer proteins encoded by broad host range fungi likely increase natural selection on codon optimization in these species. Accordingly, codon optimization correlates with host range across the fungal kingdom. At the species level, biased patterns of synonymous substitutions underpin increased codon optimization in a generalist but not a specialist fungal pathogen. Virulence genes were consistently enriched in highly codon-optimized genes of generalist but not specialist species. We conclude that codon optimization is related to the capacity of parasites to colonize multiple hosts. Our results link genome evolution and translational regulation to the long-term persistence of generalist parasitism. 2017 Journal Article http://hdl.handle.net/20.500.11937/50320 10.7554/eLife.22472 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Badet, T. Peyraud, R. Mbengue, M. Navaud, O. Derbyshire, Mark Oliver, Richard Barbacci, A. Raffaele, S. Codon optimization underpins generalist parasitism in fungi |
| title | Codon optimization underpins generalist parasitism in fungi |
| title_full | Codon optimization underpins generalist parasitism in fungi |
| title_fullStr | Codon optimization underpins generalist parasitism in fungi |
| title_full_unstemmed | Codon optimization underpins generalist parasitism in fungi |
| title_short | Codon optimization underpins generalist parasitism in fungi |
| title_sort | codon optimization underpins generalist parasitism in fungi |
| url | http://hdl.handle.net/20.500.11937/50320 |