Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease

Canonical Hedgehog (Hh) signaling in vertebrate cells occurs following Smoothened activation/translocation into the primary cilia (Pc), followed by a GLI transcriptional response. Nonetheless, GLI activation can occur independently of the canonical Hh pathway. Using a murine model of liver injury, w...

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Bibliographic Details
Main Authors: Grzelak, C., Sigglekow, N., Tirnitz-Parker, Nina, Hamson, E., Warren, A., Maneck, B., Chen, J., Patkunanathan, B., Boland, J., Cheng, R., Shackel, N., Seth, D., Bowen, D., Martelotto, L., Watkins, D., McCaughan, G.
Format: Journal Article
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/20.500.11937/50290

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