Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles
The low take-home baby rate in older women in Australia (5.8%) undergoing IVF is linked to the depletion of the ovarian reserve of primordial follicles. Oocyte depletion causes an irreversible change to ovarian function. We found that the young patient FSH receptor and LH receptor expression profile...
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| Format: | Journal Article |
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Elsevier Ireland Ltd
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/50214 |
| _version_ | 1848758423152230400 |
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| author | Regan, Sheena Knight, P. Yovich, John Stanger, J. Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam Almahbobi, Ghanim |
| author_facet | Regan, Sheena Knight, P. Yovich, John Stanger, J. Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam Almahbobi, Ghanim |
| author_sort | Regan, Sheena |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The low take-home baby rate in older women in Australia (5.8%) undergoing IVF is linked to the depletion of the ovarian reserve of primordial follicles. Oocyte depletion causes an irreversible change to ovarian function. We found that the young patient FSH receptor and LH receptor expression profile on the granulosa cells collected from different size follicles were similar to the expression profile reported in natural cycles in women and sheep. This was reversed in the older patients with poor ovarian reserve. The strong correlation of BMPR1B and FSH receptor density in the young was not present in the older women; whereas, the LH receptor and BMPR1B correlation was weak in the young but was strongly correlated in the older women. The reduced fertilisation and pregnancy rate was associated with a lower LH receptor density and a lack of essential down-regulation of the FSH and LH receptor. The mechanism regulating FSH and LH receptor expression appears to function independently, in vivo, from the dose of FSH gonadotrophin, rather than in response to it. Restoring an optimum receptor density may improve oocyte quality and the pregnancy rate in older women. |
| first_indexed | 2025-11-14T09:43:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-50214 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:43:45Z |
| publishDate | 2017 |
| publisher | Elsevier Ireland Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-502142017-09-13T15:37:22Z Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles Regan, Sheena Knight, P. Yovich, John Stanger, J. Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam Almahbobi, Ghanim The low take-home baby rate in older women in Australia (5.8%) undergoing IVF is linked to the depletion of the ovarian reserve of primordial follicles. Oocyte depletion causes an irreversible change to ovarian function. We found that the young patient FSH receptor and LH receptor expression profile on the granulosa cells collected from different size follicles were similar to the expression profile reported in natural cycles in women and sheep. This was reversed in the older patients with poor ovarian reserve. The strong correlation of BMPR1B and FSH receptor density in the young was not present in the older women; whereas, the LH receptor and BMPR1B correlation was weak in the young but was strongly correlated in the older women. The reduced fertilisation and pregnancy rate was associated with a lower LH receptor density and a lack of essential down-regulation of the FSH and LH receptor. The mechanism regulating FSH and LH receptor expression appears to function independently, in vivo, from the dose of FSH gonadotrophin, rather than in response to it. Restoring an optimum receptor density may improve oocyte quality and the pregnancy rate in older women. 2017 Journal Article http://hdl.handle.net/20.500.11937/50214 10.1016/j.mce.2017.02.007 Elsevier Ireland Ltd restricted |
| spellingShingle | Regan, Sheena Knight, P. Yovich, John Stanger, J. Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam Almahbobi, Ghanim Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles |
| title | Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles |
| title_full | Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles |
| title_fullStr | Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles |
| title_full_unstemmed | Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles |
| title_short | Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles |
| title_sort | infertility and ovarian follicle reserve depletion are associated with dysregulation of the fsh and lh receptor density in human antral follicles |
| url | http://hdl.handle.net/20.500.11937/50214 |