Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths
BACKGROUND: In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from colorectal cancer. METHODS: We included in this analysis all patients prospectively...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
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Massachusetts Medical Society
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/50143 |
| _version_ | 1848758405056954368 |
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| author | Zauber, A. Winawer, S. O'Brien, M. Lansdorp_Vogelaar, Iris Van Ballegooijen, M. Hankey, B. Shi, W. Bond, J. Schapiro, M. Panish, J. Stewart, E. Waye, J. |
| author_facet | Zauber, A. Winawer, S. O'Brien, M. Lansdorp_Vogelaar, Iris Van Ballegooijen, M. Hankey, B. Shi, W. Bond, J. Schapiro, M. Panish, J. Stewart, E. Waye, J. |
| author_sort | Zauber, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | BACKGROUND: In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from colorectal cancer. METHODS: We included in this analysis all patients prospectively referred for initial colonoscopy (between 1980 and 1990) at NPS clinical centers who had polyps (adenomas and nonadenomas). The National Death Index was used to identify deaths and to determine the cause of death; follow-up time was as long as 23 years. Mortality from colorectal cancer among patients with adenomas removed was compared with the expected incidence-based mortality from colorectal cancer in the general population, as estimated from the Surveillance Epidemiology and End Results (SEER) Program, and with the observed mortality from colorectal cancer among patients with nonadenomatous polyps (internal control group). RESULTS: Among 2602 patients who had adenomas removed during participation in the study, after a median of 15.8 years, 1246 patients had died from any cause and 12 had died from colorectal cancer. Given an estimated 25.4 expected deaths from colorectal cancer in the general population, the standardized incidence-based mortality ratio was 0.47 (95% confidence interval [CI], 0.26 to 0.80) with colonoscopic polypectomy, suggesting a 53% reduction in mortality. Mortality from colorectal cancer was similar among patients with adenomas and those with nonadenomatous polyps during the first 10 years after polypectomy (relative risk, 1.2; 95% CI, 0.1 to 10.6). CONCLUSIONS: These findings support the hypothesis that colonoscopic removal of adenomatous polyps prevents death from colorectal cancer. (Funded by the National Cancer Institute and others.) |
| first_indexed | 2025-11-14T09:43:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-50143 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:43:28Z |
| publishDate | 2012 |
| publisher | Massachusetts Medical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-501432017-09-13T15:49:10Z Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths Zauber, A. Winawer, S. O'Brien, M. Lansdorp_Vogelaar, Iris Van Ballegooijen, M. Hankey, B. Shi, W. Bond, J. Schapiro, M. Panish, J. Stewart, E. Waye, J. BACKGROUND: In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from colorectal cancer. METHODS: We included in this analysis all patients prospectively referred for initial colonoscopy (between 1980 and 1990) at NPS clinical centers who had polyps (adenomas and nonadenomas). The National Death Index was used to identify deaths and to determine the cause of death; follow-up time was as long as 23 years. Mortality from colorectal cancer among patients with adenomas removed was compared with the expected incidence-based mortality from colorectal cancer in the general population, as estimated from the Surveillance Epidemiology and End Results (SEER) Program, and with the observed mortality from colorectal cancer among patients with nonadenomatous polyps (internal control group). RESULTS: Among 2602 patients who had adenomas removed during participation in the study, after a median of 15.8 years, 1246 patients had died from any cause and 12 had died from colorectal cancer. Given an estimated 25.4 expected deaths from colorectal cancer in the general population, the standardized incidence-based mortality ratio was 0.47 (95% confidence interval [CI], 0.26 to 0.80) with colonoscopic polypectomy, suggesting a 53% reduction in mortality. Mortality from colorectal cancer was similar among patients with adenomas and those with nonadenomatous polyps during the first 10 years after polypectomy (relative risk, 1.2; 95% CI, 0.1 to 10.6). CONCLUSIONS: These findings support the hypothesis that colonoscopic removal of adenomatous polyps prevents death from colorectal cancer. (Funded by the National Cancer Institute and others.) 2012 Journal Article http://hdl.handle.net/20.500.11937/50143 10.1056/NEJMoa1100370 Massachusetts Medical Society fulltext |
| spellingShingle | Zauber, A. Winawer, S. O'Brien, M. Lansdorp_Vogelaar, Iris Van Ballegooijen, M. Hankey, B. Shi, W. Bond, J. Schapiro, M. Panish, J. Stewart, E. Waye, J. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| title | Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| title_full | Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| title_fullStr | Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| title_full_unstemmed | Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| title_short | Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| title_sort | colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths |
| url | http://hdl.handle.net/20.500.11937/50143 |