Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins
INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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2017
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| Online Access: | http://hdl.handle.net/20.500.11937/50100 |
| _version_ | 1848758394023837696 |
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| author | Munro, A. Codde, J. Spilsbury, Katrina Stewart, C. Steel, N. Leung, Y. Tan, J. Salfinger, S. Mohan, G. Semmens, James Cohen, P. |
| author_facet | Munro, A. Codde, J. Spilsbury, Katrina Stewart, C. Steel, N. Leung, Y. Tan, J. Salfinger, S. Mohan, G. Semmens, James Cohen, P. |
| author_sort | Munro, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia (AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)) and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins. MATERIAL AND METHODS: A retrospective, population-based study of Western Australian women treated by CKC or LEEP for AIS between 2001 and 2012. Histopathology reports were reviewed for demographic information, treatment procedures and clinicopathological factors. Primary outcomes were the diagnosis of cervical neoplasia during follow-up (defined as <12 months) and surveillance (=12 months) periods. RESULTS: The cohort comprised 360 women, with 175 (48.6%) initially treated by CKC and 185 (51.4%) treated by LEEP. The median patient age at time of excisional treatment was 30.0 years (range 18 to 64 years) and the median follow-up time was 3.9 years (range 6 months to 12.2 years). During the follow-up and surveillance periods, 7 (1.9%) women were diagnosed with CIN 2/3, 10 (2.8%) with AIS and 1 (0.3%) with cervical adenocarcinoma, despite their initial excision specimens having negative histological margins. CONCLUSIONS: In this study, there was a low but significant risk of persistent or recurrent cervical neoplasia in women who had initial conservative management of AIS with negative histopathological margins. This article is protected by copyright. All rights reserved. |
| first_indexed | 2025-11-14T09:43:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-50100 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:43:17Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-501002017-09-13T15:37:03Z Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins Munro, A. Codde, J. Spilsbury, Katrina Stewart, C. Steel, N. Leung, Y. Tan, J. Salfinger, S. Mohan, G. Semmens, James Cohen, P. INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia (AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)) and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins. MATERIAL AND METHODS: A retrospective, population-based study of Western Australian women treated by CKC or LEEP for AIS between 2001 and 2012. Histopathology reports were reviewed for demographic information, treatment procedures and clinicopathological factors. Primary outcomes were the diagnosis of cervical neoplasia during follow-up (defined as <12 months) and surveillance (=12 months) periods. RESULTS: The cohort comprised 360 women, with 175 (48.6%) initially treated by CKC and 185 (51.4%) treated by LEEP. The median patient age at time of excisional treatment was 30.0 years (range 18 to 64 years) and the median follow-up time was 3.9 years (range 6 months to 12.2 years). During the follow-up and surveillance periods, 7 (1.9%) women were diagnosed with CIN 2/3, 10 (2.8%) with AIS and 1 (0.3%) with cervical adenocarcinoma, despite their initial excision specimens having negative histological margins. CONCLUSIONS: In this study, there was a low but significant risk of persistent or recurrent cervical neoplasia in women who had initial conservative management of AIS with negative histopathological margins. This article is protected by copyright. All rights reserved. 2017 Journal Article http://hdl.handle.net/20.500.11937/50100 10.1111/aogs.13110 restricted |
| spellingShingle | Munro, A. Codde, J. Spilsbury, Katrina Stewart, C. Steel, N. Leung, Y. Tan, J. Salfinger, S. Mohan, G. Semmens, James Cohen, P. Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| title | Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| title_full | Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| title_fullStr | Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| title_full_unstemmed | Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| title_short | Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| title_sort | risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins |
| url | http://hdl.handle.net/20.500.11937/50100 |