How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer?
BACKGROUND: Individuals with a family history of colorectal cancer (CRC) are at increased risk for CRC. Current screening recommendations for these individuals are based on expert opinion. The authors investigated optimal screening strategies for individuals with various degrees of family history of...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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John Wiley & Sons, Inc.
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/49969 |
| _version_ | 1848758362308608000 |
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| author | Wilschut, J. Steyerberg, E. Van Leerdam, M. Lansdorp_Vogelaar, Iris Habbema, J. Van Ballegooijen, M. |
| author_facet | Wilschut, J. Steyerberg, E. Van Leerdam, M. Lansdorp_Vogelaar, Iris Habbema, J. Van Ballegooijen, M. |
| author_sort | Wilschut, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | BACKGROUND: Individuals with a family history of colorectal cancer (CRC) are at increased risk for CRC. Current screening recommendations for these individuals are based on expert opinion. The authors investigated optimal screening strategies for individuals with various degrees of family history of CRC based on a cost-effectiveness analysis. METHODS: The MISCAN-Colon microsimulation model was used to estimate costs and effects of CRC screening strategies, varying by the age at which screening was started and stopped and by screening interval. The authors defined 4 risk groups, characterized by the number of affected first-degree relatives and their age at CRC diagnosis. For all risk groups, the optimal screening strategy had an incremental cost-effectiveness ratio of approximately $50,000 per life-year gained. RESULTS: The optimal screening strategy for individuals with 1 first-degree relative diagnosed after age 50 years was 6 colonoscopies every 5 years starting at age 50 years, compared with 4 colonoscopies every 7 years starting at age 50 years for average risk individuals. The optimal strategy had 10 colonoscopies every 4 years for individuals with 1 first-degree relative diagnosed before age 50 years, 13 colonoscopies every 3 years for individuals with 2 or more first-degree relatives diagnosed after age 50 years, and 15 colonoscopies every 3 years for individuals with 2 or more first-degree relatives of whom at least 1 was diagnosed before age 50 years. CONCLUSIONS: The optimal screening strategy varies considerably with the number of affected first-degree relatives and their age of diagnosis. Shorter screening intervals than the currently recommended 5 years may be appropriate for the highest risk individuals. © 2011 American Cancer Society. |
| first_indexed | 2025-11-14T09:42:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-49969 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:42:47Z |
| publishDate | 2011 |
| publisher | John Wiley & Sons, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-499692017-09-13T15:49:10Z How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? Wilschut, J. Steyerberg, E. Van Leerdam, M. Lansdorp_Vogelaar, Iris Habbema, J. Van Ballegooijen, M. BACKGROUND: Individuals with a family history of colorectal cancer (CRC) are at increased risk for CRC. Current screening recommendations for these individuals are based on expert opinion. The authors investigated optimal screening strategies for individuals with various degrees of family history of CRC based on a cost-effectiveness analysis. METHODS: The MISCAN-Colon microsimulation model was used to estimate costs and effects of CRC screening strategies, varying by the age at which screening was started and stopped and by screening interval. The authors defined 4 risk groups, characterized by the number of affected first-degree relatives and their age at CRC diagnosis. For all risk groups, the optimal screening strategy had an incremental cost-effectiveness ratio of approximately $50,000 per life-year gained. RESULTS: The optimal screening strategy for individuals with 1 first-degree relative diagnosed after age 50 years was 6 colonoscopies every 5 years starting at age 50 years, compared with 4 colonoscopies every 7 years starting at age 50 years for average risk individuals. The optimal strategy had 10 colonoscopies every 4 years for individuals with 1 first-degree relative diagnosed before age 50 years, 13 colonoscopies every 3 years for individuals with 2 or more first-degree relatives diagnosed after age 50 years, and 15 colonoscopies every 3 years for individuals with 2 or more first-degree relatives of whom at least 1 was diagnosed before age 50 years. CONCLUSIONS: The optimal screening strategy varies considerably with the number of affected first-degree relatives and their age of diagnosis. Shorter screening intervals than the currently recommended 5 years may be appropriate for the highest risk individuals. © 2011 American Cancer Society. 2011 Journal Article http://hdl.handle.net/20.500.11937/49969 10.1002/cncr.26009 John Wiley & Sons, Inc. unknown |
| spellingShingle | Wilschut, J. Steyerberg, E. Van Leerdam, M. Lansdorp_Vogelaar, Iris Habbema, J. Van Ballegooijen, M. How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| title | How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| title_full | How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| title_fullStr | How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| title_full_unstemmed | How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| title_short | How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| title_sort | how much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer? |
| url | http://hdl.handle.net/20.500.11937/49969 |