Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer
Objective: Limited data exist on attendance and additional yield of 2-sample faecal immunochemical testing (FIT) screening during multiple rounds. We therefore conducted a population-based colorectal cancer screening trial comparing attendance and yield of repeated 1-sample and 2-sample FIT screenin...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/49863 |
| _version_ | 1848758334228791296 |
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| author | Kapidzic, A. van Roon, A. van Leerdam, M. van Vuuren, A. van Ballegooijen, M. Lansdorp-Vogelaar, Iris Spijker, W. Izelaar, K. Hol, L. Kuipers, E. |
| author_facet | Kapidzic, A. van Roon, A. van Leerdam, M. van Vuuren, A. van Ballegooijen, M. Lansdorp-Vogelaar, Iris Spijker, W. Izelaar, K. Hol, L. Kuipers, E. |
| author_sort | Kapidzic, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: Limited data exist on attendance and additional yield of 2-sample faecal immunochemical testing (FIT) screening during multiple rounds. We therefore conducted a population-based colorectal cancer screening trial comparing attendance and yield of repeated 1-sample and 2-sample FIT screenings. Design: Two randomly selected groups of average-risk subjects aged 50-74 years were invited for two rounds of either 1-sample (n=5007) or 2-sample (n=3197) FIT (OC-sensor Micro) screening. The test was considered positive if at least one sample was positive (cut-off 50 ng/mL; 10 µg haemoglobin/g). Results: The cumulative attendance rate was similar for repeated 1-sample and 2-sample FIT screenings (1-sample FIT: 68.1%; 2-sample FIT: 67.1%, p=0.368). The positivity rate in the second round was lower for 1-sample FIT (6.2%, 95% CI 5.4% to 7.2%) than for 2-sample FIT (8.4%, 95% CI 7.1% to 9.8%, p=0.007), whereas the detection rate of advanced neoplasia (AN, 1-sample FIT: 1.9%, 95% CI 1.2% to 2.2%; 2-sample FIT: 1.7%, 95% CI 1.2% to 2.5%, p=0.861) and the positive predictive value (1-sample FIT: 32%, 95% CI 24% to 40%; 2-sample FIT: 21%, 95% CI 15% to 29%, p=0.075) did not differ. After two rounds of screening, the cumulative diagnostic yield of AN for 1-sample FIT was 29.3 per 1000 invitees, compared with 34.0 for 2-sample FIT (p=0.241). Conclusions: Using 2-sample FIT instead of 1-sample FIT does not result in a higher detection rate of AN in the second round of repeated FIT screening. Furthermore, both strategies lead to a similar yield of AN over two rounds. These findings imply that 1-sample FIT screening is preferred over 2-sample FIT screening. |
| first_indexed | 2025-11-14T09:42:20Z |
| format | Journal Article |
| id | curtin-20.500.11937-49863 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:42:20Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-498632017-09-13T16:09:44Z Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer Kapidzic, A. van Roon, A. van Leerdam, M. van Vuuren, A. van Ballegooijen, M. Lansdorp-Vogelaar, Iris Spijker, W. Izelaar, K. Hol, L. Kuipers, E. Objective: Limited data exist on attendance and additional yield of 2-sample faecal immunochemical testing (FIT) screening during multiple rounds. We therefore conducted a population-based colorectal cancer screening trial comparing attendance and yield of repeated 1-sample and 2-sample FIT screenings. Design: Two randomly selected groups of average-risk subjects aged 50-74 years were invited for two rounds of either 1-sample (n=5007) or 2-sample (n=3197) FIT (OC-sensor Micro) screening. The test was considered positive if at least one sample was positive (cut-off 50 ng/mL; 10 µg haemoglobin/g). Results: The cumulative attendance rate was similar for repeated 1-sample and 2-sample FIT screenings (1-sample FIT: 68.1%; 2-sample FIT: 67.1%, p=0.368). The positivity rate in the second round was lower for 1-sample FIT (6.2%, 95% CI 5.4% to 7.2%) than for 2-sample FIT (8.4%, 95% CI 7.1% to 9.8%, p=0.007), whereas the detection rate of advanced neoplasia (AN, 1-sample FIT: 1.9%, 95% CI 1.2% to 2.2%; 2-sample FIT: 1.7%, 95% CI 1.2% to 2.5%, p=0.861) and the positive predictive value (1-sample FIT: 32%, 95% CI 24% to 40%; 2-sample FIT: 21%, 95% CI 15% to 29%, p=0.075) did not differ. After two rounds of screening, the cumulative diagnostic yield of AN for 1-sample FIT was 29.3 per 1000 invitees, compared with 34.0 for 2-sample FIT (p=0.241). Conclusions: Using 2-sample FIT instead of 1-sample FIT does not result in a higher detection rate of AN in the second round of repeated FIT screening. Furthermore, both strategies lead to a similar yield of AN over two rounds. These findings imply that 1-sample FIT screening is preferred over 2-sample FIT screening. 2015 Journal Article http://hdl.handle.net/20.500.11937/49863 10.1136/gutjnl-2014-308957 restricted |
| spellingShingle | Kapidzic, A. van Roon, A. van Leerdam, M. van Vuuren, A. van Ballegooijen, M. Lansdorp-Vogelaar, Iris Spijker, W. Izelaar, K. Hol, L. Kuipers, E. Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| title | Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| title_full | Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| title_fullStr | Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| title_full_unstemmed | Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| title_short | Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| title_sort | attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer |
| url | http://hdl.handle.net/20.500.11937/49863 |