Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications
Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed...
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| Format: | Thesis |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/49779 |
| _version_ | 1848758731091738624 |
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| author | Grenik, Elizabeth Monica |
| author_facet | Grenik, Elizabeth Monica |
| author_sort | Grenik, Elizabeth Monica |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed on the hydrogels with HS which enhanced myoblast differentiation. This was likely due to the improved cell organisation from cell-hydrogel interactions. The improved cell behaviour on the modified hydrogels showed potential for tissue regeneration. |
| first_indexed | 2025-11-14T09:48:39Z |
| format | Thesis |
| id | curtin-20.500.11937-49779 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:48:39Z |
| publishDate | 2016 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-497792017-03-28T04:26:22Z Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications Grenik, Elizabeth Monica Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed on the hydrogels with HS which enhanced myoblast differentiation. This was likely due to the improved cell organisation from cell-hydrogel interactions. The improved cell behaviour on the modified hydrogels showed potential for tissue regeneration. 2016 Thesis http://hdl.handle.net/20.500.11937/49779 Curtin University fulltext |
| spellingShingle | Grenik, Elizabeth Monica Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications |
| title | Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications |
| title_full | Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications |
| title_fullStr | Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications |
| title_full_unstemmed | Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications |
| title_short | Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications |
| title_sort | chemical modification of phema to create an improved bioactive biomaterial for regenerative applications |
| url | http://hdl.handle.net/20.500.11937/49779 |