Patient blood management is a win-win: a wake -up call
Preoperative anaemia is frequent in surgical patients and increases postoperative mortality, major morbidity, and length of hospital stay. Poorly controlled bleeding and surgical blood loss can also contribute to these outcomes. Anaemia, blood loss, and liberal transfusion triggers are the main pred...
| Main Authors: | , , |
|---|---|
| Format: | Journal Article |
| Published: |
Oxford University Press
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/49645 |
| _version_ | 1848758285069451264 |
|---|---|
| author | Spahn, D. Theusinger, O. Hofmann, Axel |
| author_facet | Spahn, D. Theusinger, O. Hofmann, Axel |
| author_sort | Spahn, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Preoperative anaemia is frequent in surgical patients and increases postoperative mortality, major morbidity, and length of hospital stay. Poorly controlled bleeding and surgical blood loss can also contribute to these outcomes. Anaemia, blood loss, and liberal transfusion triggers are the main predictors for red blood cell (RBC) transfusion. RBC transfusion in turn is an additional independent predictor for adverse outcome and has therefore been referred to as the ‘second hit’ for the recipient. Transfusion outcomes include higher mortality, more ischaemic complications, organ dysfunction, infections, delayed wound healing, and increased length of hospital stay. Transfused patients may also be more likely to develop non-Hodgkin lymphoma. Interestingly, most of these complications are found after administration of just a single RBC unit.1011 Strict application of the Bradford-Hill criteria strongly suggests that the link between transfusion and adverse outcomes is causal and not just associative. |
| first_indexed | 2025-11-14T09:41:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-49645 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:41:33Z |
| publishDate | 2012 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-496452017-03-15T22:56:19Z Patient blood management is a win-win: a wake -up call Spahn, D. Theusinger, O. Hofmann, Axel blood loss anaemia mortality transfusion morbidity patient blood management Preoperative anaemia is frequent in surgical patients and increases postoperative mortality, major morbidity, and length of hospital stay. Poorly controlled bleeding and surgical blood loss can also contribute to these outcomes. Anaemia, blood loss, and liberal transfusion triggers are the main predictors for red blood cell (RBC) transfusion. RBC transfusion in turn is an additional independent predictor for adverse outcome and has therefore been referred to as the ‘second hit’ for the recipient. Transfusion outcomes include higher mortality, more ischaemic complications, organ dysfunction, infections, delayed wound healing, and increased length of hospital stay. Transfused patients may also be more likely to develop non-Hodgkin lymphoma. Interestingly, most of these complications are found after administration of just a single RBC unit.1011 Strict application of the Bradford-Hill criteria strongly suggests that the link between transfusion and adverse outcomes is causal and not just associative. 2012 Journal Article http://hdl.handle.net/20.500.11937/49645 Oxford University Press restricted |
| spellingShingle | blood loss anaemia mortality transfusion morbidity patient blood management Spahn, D. Theusinger, O. Hofmann, Axel Patient blood management is a win-win: a wake -up call |
| title | Patient blood management is a win-win: a wake -up call |
| title_full | Patient blood management is a win-win: a wake -up call |
| title_fullStr | Patient blood management is a win-win: a wake -up call |
| title_full_unstemmed | Patient blood management is a win-win: a wake -up call |
| title_short | Patient blood management is a win-win: a wake -up call |
| title_sort | patient blood management is a win-win: a wake -up call |
| topic | blood loss anaemia mortality transfusion morbidity patient blood management |
| url | http://hdl.handle.net/20.500.11937/49645 |