The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes
Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potentnano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge.Here, we report the cell penetrating peptide catalyzed formation of antimicrobial sil...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
R S C Publications
2013
|
| Online Access: | http://hdl.handle.net/20.500.11937/49540 |
| _version_ | 1848758261669429248 |
|---|---|
| author | Liu, Lihong Yang, J. Xie, J. Luo, Z. Jiang, J. Yang, Y.Y. Liu, Shaomin |
| author_facet | Liu, Lihong Yang, J. Xie, J. Luo, Z. Jiang, J. Yang, Y.Y. Liu, Shaomin |
| author_sort | Liu, Lihong |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potentnano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge.Here, we report the cell penetrating peptide catalyzed formation of antimicrobial silver nanoparticles inN,N-dimethylformamide. The novel nano-composite demonstrated a distinctly enhanced biocidal effecttoward bacteria (Gram-positive Bacillus subtilis, Gram-negative Escherichia coli) and pathogenic yeast(Candida albicans), as compared to triangular and extremely small silver nanoparticles. In addition, asatisfactory biocompatibility was verified by a haemolysis test. Our results provide a paradigm indeveloping strategies that can maximize the silver nanoparticle application potentials while minimizingthe toxic effects. |
| first_indexed | 2025-11-14T09:41:11Z |
| format | Journal Article |
| id | curtin-20.500.11937-49540 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:41:11Z |
| publishDate | 2013 |
| publisher | R S C Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-495402017-09-13T15:36:41Z The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes Liu, Lihong Yang, J. Xie, J. Luo, Z. Jiang, J. Yang, Y.Y. Liu, Shaomin Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potentnano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge.Here, we report the cell penetrating peptide catalyzed formation of antimicrobial silver nanoparticles inN,N-dimethylformamide. The novel nano-composite demonstrated a distinctly enhanced biocidal effecttoward bacteria (Gram-positive Bacillus subtilis, Gram-negative Escherichia coli) and pathogenic yeast(Candida albicans), as compared to triangular and extremely small silver nanoparticles. In addition, asatisfactory biocompatibility was verified by a haemolysis test. Our results provide a paradigm indeveloping strategies that can maximize the silver nanoparticle application potentials while minimizingthe toxic effects. 2013 Journal Article http://hdl.handle.net/20.500.11937/49540 10.1039/C3NR34254A R S C Publications restricted |
| spellingShingle | Liu, Lihong Yang, J. Xie, J. Luo, Z. Jiang, J. Yang, Y.Y. Liu, Shaomin The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes |
| title | The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes |
| title_full | The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes |
| title_fullStr | The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes |
| title_full_unstemmed | The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes |
| title_short | The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes |
| title_sort | potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for gram-positive bacteria over erythrocytes |
| url | http://hdl.handle.net/20.500.11937/49540 |