Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes
Objective: To assess the glucagon response to hypoglycemia and identify influencing factors in patients with type 1 diabetes compared with nondiabetic control subjects.Research design and methods - Hyperinsulinemic hypoglycemic clamp studies were performed in all participants. The glucagon response...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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American Diabetes Association
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/49429 |
| _version_ | 1848758237609852928 |
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| author | Siafarikas, A. Johnston, R. Bulsara, M. O'Leary, Peter Jones, T. Davis, E. |
| author_facet | Siafarikas, A. Johnston, R. Bulsara, M. O'Leary, Peter Jones, T. Davis, E. |
| author_sort | Siafarikas, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: To assess the glucagon response to hypoglycemia and identify influencing factors in patients with type 1 diabetes compared with nondiabetic control subjects.Research design and methods - Hyperinsulinemic hypoglycemic clamp studies were performed in all participants. The glucagon response to both hypoglycemia and arginine was measured, as well as epinephrine, cortisol, and growth hormone responses to hypoglycemia. Residual ß-cell function was assessed using fasting and stimulated C-peptide.Conclusions - The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disesase. |
| first_indexed | 2025-11-14T09:40:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-49429 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:40:48Z |
| publishDate | 2012 |
| publisher | American Diabetes Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-494292017-05-22T06:00:24Z Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes Siafarikas, A. Johnston, R. Bulsara, M. O'Leary, Peter Jones, T. Davis, E. glucagon response hypoglycemia type 1 diabetes Objective: To assess the glucagon response to hypoglycemia and identify influencing factors in patients with type 1 diabetes compared with nondiabetic control subjects.Research design and methods - Hyperinsulinemic hypoglycemic clamp studies were performed in all participants. The glucagon response to both hypoglycemia and arginine was measured, as well as epinephrine, cortisol, and growth hormone responses to hypoglycemia. Residual ß-cell function was assessed using fasting and stimulated C-peptide.Conclusions - The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disesase. 2012 Journal Article http://hdl.handle.net/20.500.11937/49429 http://creativecommons.org/licenses/by-nc-nd/3.0/ American Diabetes Association fulltext |
| spellingShingle | glucagon response hypoglycemia type 1 diabetes Siafarikas, A. Johnston, R. Bulsara, M. O'Leary, Peter Jones, T. Davis, E. Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes |
| title | Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes |
| title_full | Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes |
| title_fullStr | Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes |
| title_full_unstemmed | Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes |
| title_short | Early Loss of the Glucagon Response to Hypoglycemia in Adolescents with Type 1 Diabetes |
| title_sort | early loss of the glucagon response to hypoglycemia in adolescents with type 1 diabetes |
| topic | glucagon response hypoglycemia type 1 diabetes |
| url | http://hdl.handle.net/20.500.11937/49429 |