Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responses

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Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responses

Targeting interleukin-2 (IL-2) and/or agonist anti-CD40 antibody (Ab) into tumors represents an effective vaccination strategy that avoids systemic toxicity and resolves treated-site tumors. Here, we examined IL-2 and/or anti-CD40 Ab-driven local versus systemic T cell function and the installation...

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Bibliographic Details
Main Authors:	Jackaman, Connie, Nelson, Delia
Format:	Journal Article
Published:	Springer 2012
Subjects:	Tumor immunity Memory CD8? T cells CD4? T cells
Online Access:	http://link.springer.de/link/service/journals/00262/index.htm http://hdl.handle.net/20.500.11937/49275

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