Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis
The studies in this thesis aimed to characterise liver progenitor cells and their microenvironment during chronic liver injury conditions. A comprehensive comparison of the two common murine chronic liver disease models, CDE versus TAA, was performed. Parameters such as hepatocyte health, inflammati...
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| Format: | Thesis |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/48824 |
| Summary: | The studies in this thesis aimed to characterise liver progenitor cells and their microenvironment during chronic liver injury conditions. A comprehensive comparison of the two common murine chronic liver disease models, CDE versus TAA, was performed. Parameters such as hepatocyte health, inflammation, fibrosis and the LPC response were investigated during stages of injury induction, establishment, maintenance, progression and carcinogenesis. Furthermore, the relationship between LPCs and HCC development in humans was investigated in a retrospective study. |
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