Cytokines in alphavirus induced arthritis as possible targets for novel treatments
This study highlighted the involvement of macrophages, muscle cells and adipocytes in the pathogenesis of RRV disease and investigated the release of various cytokines from these cells during infection, such as TNFα, MIF, NO, HMGB proteins, IL-6, IL-18, IL-33, IL-10 and others. Several known cytokin...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/48524 |
| _version_ | 1848758108524904448 |
|---|---|
| author | Wimmer, Wolfgang |
| author_facet | Wimmer, Wolfgang |
| author_sort | Wimmer, Wolfgang |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study highlighted the involvement of macrophages, muscle cells and adipocytes in the pathogenesis of RRV disease and investigated the release of various cytokines from these cells during infection, such as TNFα, MIF, NO, HMGB proteins, IL-6, IL-18, IL-33, IL-10 and others. Several known cytokine inhibitors were tested for their anti-inflammatory properties in RRV infected cell lines as possible future treatment options. These inhibitors included erythromycin, clarithromycin, roxithromycin, ethyl pyruvate, pentoxifylline and resveratrol. |
| first_indexed | 2025-11-14T09:38:45Z |
| format | Thesis |
| id | curtin-20.500.11937-48524 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:38:45Z |
| publishDate | 2015 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-485242017-02-09T01:10:10Z Cytokines in alphavirus induced arthritis as possible targets for novel treatments Wimmer, Wolfgang This study highlighted the involvement of macrophages, muscle cells and adipocytes in the pathogenesis of RRV disease and investigated the release of various cytokines from these cells during infection, such as TNFα, MIF, NO, HMGB proteins, IL-6, IL-18, IL-33, IL-10 and others. Several known cytokine inhibitors were tested for their anti-inflammatory properties in RRV infected cell lines as possible future treatment options. These inhibitors included erythromycin, clarithromycin, roxithromycin, ethyl pyruvate, pentoxifylline and resveratrol. 2015 Thesis http://hdl.handle.net/20.500.11937/48524 Curtin University fulltext |
| spellingShingle | Wimmer, Wolfgang Cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| title | Cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| title_full | Cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| title_fullStr | Cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| title_full_unstemmed | Cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| title_short | Cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| title_sort | cytokines in alphavirus induced arthritis as possible targets for novel treatments |
| url | http://hdl.handle.net/20.500.11937/48524 |