Stereoselective Binding of Human Serum Albumin
Stereoselectivity in binding can have a significant effect on the drug disposition such as first-pass metabolism, metabolic clearance, renal clearance, and protein and tissue binding. Human serum albumin (HSA) is able to stereoselectively bind a great number of various endogenous and exogenous compo...
| Main Authors: | , |
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| Format: | Journal Article |
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Wiley-Liss
2006
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| Online Access: | http://hdl.handle.net/20.500.11937/48357 |
| _version_ | 1848758086676774912 |
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| author | Chuang, Victor Otagiri, M. |
| author_facet | Chuang, Victor Otagiri, M. |
| author_sort | Chuang, Victor |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Stereoselectivity in binding can have a significant effect on the drug disposition such as first-pass metabolism, metabolic clearance, renal clearance, and protein and tissue binding. Human serum albumin (HSA) is able to stereoselectively bind a great number of various endogenous and exogenous compounds. Various experimental data suggested that the two major drug-binding cavities, namely, site I and site II, do not seem to be the stereoselective binding sites of HSA. Stereoselective binding of HSA under disease conditions such as renal and hepatic diseases was found to be enhanced. In addition, site-to-site displacement of a site II-specific drug by another site II-specific drug was found to be stereoselective, too. Endogenous compounds such as long-chain fatty acids and uremic toxins are likely to cause combined direct and cascade effects that contribute to the preferential binding of a particular drug enantiomer. Taking together the findings of other studies, it is highly possible that the stereoselective binding site exists at the interface of the subdomains. |
| first_indexed | 2025-11-14T09:38:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-48357 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:38:24Z |
| publishDate | 2006 |
| publisher | Wiley-Liss |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-483572017-09-13T15:59:13Z Stereoselective Binding of Human Serum Albumin Chuang, Victor Otagiri, M. binding site allosteric interaction subdomain stereoselective binding human serum albumin Stereoselectivity in binding can have a significant effect on the drug disposition such as first-pass metabolism, metabolic clearance, renal clearance, and protein and tissue binding. Human serum albumin (HSA) is able to stereoselectively bind a great number of various endogenous and exogenous compounds. Various experimental data suggested that the two major drug-binding cavities, namely, site I and site II, do not seem to be the stereoselective binding sites of HSA. Stereoselective binding of HSA under disease conditions such as renal and hepatic diseases was found to be enhanced. In addition, site-to-site displacement of a site II-specific drug by another site II-specific drug was found to be stereoselective, too. Endogenous compounds such as long-chain fatty acids and uremic toxins are likely to cause combined direct and cascade effects that contribute to the preferential binding of a particular drug enantiomer. Taking together the findings of other studies, it is highly possible that the stereoselective binding site exists at the interface of the subdomains. 2006 Journal Article http://hdl.handle.net/20.500.11937/48357 10.1002/chir.20237 Wiley-Liss restricted |
| spellingShingle | binding site allosteric interaction subdomain stereoselective binding human serum albumin Chuang, Victor Otagiri, M. Stereoselective Binding of Human Serum Albumin |
| title | Stereoselective Binding of Human Serum Albumin |
| title_full | Stereoselective Binding of Human Serum Albumin |
| title_fullStr | Stereoselective Binding of Human Serum Albumin |
| title_full_unstemmed | Stereoselective Binding of Human Serum Albumin |
| title_short | Stereoselective Binding of Human Serum Albumin |
| title_sort | stereoselective binding of human serum albumin |
| topic | binding site allosteric interaction subdomain stereoselective binding human serum albumin |
| url | http://hdl.handle.net/20.500.11937/48357 |