The Facial Evolution: Looking Backward and Moving Forward
Three-dimensional (3D) facial analysis is ideal for high-resolution, nonionizing, noninvasive objective, high-throughput phenotypic, and phenomic studies. It is a natural complement to (epi)genetic technologies to facilitate advances in the understanding of rare and common diseases. The face is uniq...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Wiley Interscience
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/48349 |
| _version_ | 1848758084651974656 |
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| author | Baynam, G. Walters, M. Claes, P. Kung, S. LeSouef, P. Dawkins, Hugh Gillett, D. Goldblatt, J. |
| author_facet | Baynam, G. Walters, M. Claes, P. Kung, S. LeSouef, P. Dawkins, Hugh Gillett, D. Goldblatt, J. |
| author_sort | Baynam, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Three-dimensional (3D) facial analysis is ideal for high-resolution, nonionizing, noninvasive objective, high-throughput phenotypic, and phenomic studies. It is a natural complement to (epi)genetic technologies to facilitate advances in the understanding of rare and common diseases. The face is uniquely reflective of the primordial tissues, and there is evidence supporting the application of 3D facial analysis to the investigation of variation and disease including studies showing that the face can reflect systemic health, provides diagnostic clues to disorders, and that facial variation reflects biological pathways. In addition, facial variation has been related to evolutionary factors. The purpose of this review is to look backward to suggest that knowledge of human evolution supports, and may instruct, the application and interpretation of studies of facial morphology for documentation of human variation and investigation of its relationships with health and disease. Furthermore, in the context of advances of deep phenotyping and data integration, to look forward to suggest approaches to scalable implementation of facial analysis, and to suggest avenues for future research and clinical application of this technology. |
| first_indexed | 2025-11-14T09:38:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-48349 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:38:22Z |
| publishDate | 2013 |
| publisher | Wiley Interscience |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-483492017-09-13T14:22:50Z The Facial Evolution: Looking Backward and Moving Forward Baynam, G. Walters, M. Claes, P. Kung, S. LeSouef, P. Dawkins, Hugh Gillett, D. Goldblatt, J. vaccines rare diseases dysmorphology phenotype evolution facial analysis three dimensional Three-dimensional (3D) facial analysis is ideal for high-resolution, nonionizing, noninvasive objective, high-throughput phenotypic, and phenomic studies. It is a natural complement to (epi)genetic technologies to facilitate advances in the understanding of rare and common diseases. The face is uniquely reflective of the primordial tissues, and there is evidence supporting the application of 3D facial analysis to the investigation of variation and disease including studies showing that the face can reflect systemic health, provides diagnostic clues to disorders, and that facial variation reflects biological pathways. In addition, facial variation has been related to evolutionary factors. The purpose of this review is to look backward to suggest that knowledge of human evolution supports, and may instruct, the application and interpretation of studies of facial morphology for documentation of human variation and investigation of its relationships with health and disease. Furthermore, in the context of advances of deep phenotyping and data integration, to look forward to suggest approaches to scalable implementation of facial analysis, and to suggest avenues for future research and clinical application of this technology. 2013 Journal Article http://hdl.handle.net/20.500.11937/48349 10.1002/humu.22219 Wiley Interscience restricted |
| spellingShingle | vaccines rare diseases dysmorphology phenotype evolution facial analysis three dimensional Baynam, G. Walters, M. Claes, P. Kung, S. LeSouef, P. Dawkins, Hugh Gillett, D. Goldblatt, J. The Facial Evolution: Looking Backward and Moving Forward |
| title | The Facial Evolution: Looking Backward and Moving Forward |
| title_full | The Facial Evolution: Looking Backward and Moving Forward |
| title_fullStr | The Facial Evolution: Looking Backward and Moving Forward |
| title_full_unstemmed | The Facial Evolution: Looking Backward and Moving Forward |
| title_short | The Facial Evolution: Looking Backward and Moving Forward |
| title_sort | facial evolution: looking backward and moving forward |
| topic | vaccines rare diseases dysmorphology phenotype evolution facial analysis three dimensional |
| url | http://hdl.handle.net/20.500.11937/48349 |