Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy.
Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART)...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Mary Ann Liebert, Inc.
2016
|
| Online Access: | http://hdl.handle.net/20.500.11937/48277 |
| _version_ | 1848758065185161216 |
|---|---|
| author | Marini, S. Susufi, Y. Krisnuhoni, E. Gani, R. Yunihastuti, E. Lee, Silvia Tanaskovic, S. Price, Patricia |
| author_facet | Marini, S. Susufi, Y. Krisnuhoni, E. Gani, R. Yunihastuti, E. Lee, Silvia Tanaskovic, S. Price, Patricia |
| author_sort | Marini, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4(+) and CD8(+) cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART. |
| first_indexed | 2025-11-14T09:38:03Z |
| format | Journal Article |
| id | curtin-20.500.11937-48277 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:38:03Z |
| publishDate | 2016 |
| publisher | Mary Ann Liebert, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-482772019-02-19T05:35:17Z Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. Marini, S. Susufi, Y. Krisnuhoni, E. Gani, R. Yunihastuti, E. Lee, Silvia Tanaskovic, S. Price, Patricia Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4(+) and CD8(+) cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART. 2016 Journal Article http://hdl.handle.net/20.500.11937/48277 10.1089/AID.2016.0042 Mary Ann Liebert, Inc. fulltext |
| spellingShingle | Marini, S. Susufi, Y. Krisnuhoni, E. Gani, R. Yunihastuti, E. Lee, Silvia Tanaskovic, S. Price, Patricia Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. |
| title | Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. |
| title_full | Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. |
| title_fullStr | Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. |
| title_full_unstemmed | Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. |
| title_short | Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. |
| title_sort | few liver-infiltrating cells express cxcr3 in hiv/hcv patients commencing antiretroviral therapy. |
| url | http://hdl.handle.net/20.500.11937/48277 |