Removal of endotoxins from plasmid DNA: Analysis of aggregative interaction of mobile divalent metal cations with endotoxins and plasmid DNA

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Removal of endotoxins from plasmid DNA: Analysis of aggregative interaction of mobile divalent metal cations with endotoxins and plasmid DNA

Endotoxin lipopolysaccharide removal from plasmid DNA-based vaccine remains a very challenging task for bioprocess engineers. This paper examined the potential use and advantages of divalent cation (Zn2+, Ca2+, Mg2+) induced aggregation as a plasmid DNA purification method for lipopolysaccharide rem...

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Bibliographic Details
Main Authors:	Ongkudon, C., Hodges, E., Murphy, K., Danquah, Michael
Format:	Journal Article
Published:	2012
Online Access:	http://hdl.handle.net/20.500.11937/47699

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