Whole genomes redefine the mutational landscape of pancreatic cancer

Whole genomes redefine the mutational landscape of pancreatic cancer

Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting...

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Main Authors: Waddell, N., Pajic, M., Patch, A., Chang, D., Kassahn, K., Bailey, P., Johns, A., Miller, D., Nones, K., Quek, K., Quinn, M., Robertson, A., Fadlullah, M., Bruxner, T., Christ, A., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., Nourbakhsh, E., Wani, S., Wilson, P., Markham, E., Cloonan, N., Anderson, M., Fink, J., Holmes, O., Kazakoff, S., Leonard, C., Newell, F., Poudel, B., Song, S., Taylor, D., Wood, S., Xu, Q., Wu, J., Pinese, M., Cowley, M., Lee, H., Jones, M., Nagrial, A., Humphris, J., Chantrill, L., Chin, V., Steinmann, A., Mawson, A., Humphrey, E., Colvin, E., Chou, A., Scarlett, C., Pinho, A., Giry-Laterriere, M., Rooman, I., Samra, J., Kench, J., Pettitt, J., Merrett, N., Toon, C., Epari, K., Nguyen, N., Barbour, A., Zeps, Nikolajs, Jamieson, N., Graham, J., Niclou, S., Bjerkvig, R., Grützmann, R., Aust, D., Hruban, R., Maitra, A., Iacobuzio-Donahue, C., Wolfgang, C., Morgan, R., Lawlor, R., Corbo, V., Bassi, C., Falconi, M., Zamboni, G., Tortora, G., Tempero, M., Gill, A., Eshleman, J., Pilarsky, C., Scarpa, A., Musgrove, E., Pearson, J., Biankin, A., Grimmond, S.
Format: Journal Article
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/20.500.11937/47532

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