GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

Death-associated protein kinase (DAPk) was recently suggested by sequence homology to be a member of the ROCO family of proteins. Here, we show that DAPk has a functional ROC (Ras of complex proteins) domain that mediates homo-oligomerization and GTP binding through a defined P-loop motif. Upon bind...

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Bibliographic Details
Main Authors: Carlessi, Rodrigo, Levin-Salomon, V., Ciprut, S., Bialik, S., Berissi, H., Albeck, S., Peleg, Y., Kimchi, A.
Format: Journal Article
Published: 2011
Online Access:http://hdl.handle.net/20.500.11937/47501

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