Topical and cutaneous delivery using nanosystems
The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/47450 |
| _version_ | 1848757836825231360 |
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| author | Roberts, M. Mohammed, Y. Pastore, M. Namjoshi, S. Yousef, S. Alinaghi, A. Haridass, I. Abd, E. Leite-Silva, V. Benson, Heather Grice, J. |
| author_facet | Roberts, M. Mohammed, Y. Pastore, M. Namjoshi, S. Yousef, S. Alinaghi, A. Haridass, I. Abd, E. Leite-Silva, V. Benson, Heather Grice, J. |
| author_sort | Roberts, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review. |
| first_indexed | 2025-11-14T09:34:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-47450 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:34:26Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-474502025-03-27T05:27:07Z Topical and cutaneous delivery using nanosystems Roberts, M. Mohammed, Y. Pastore, M. Namjoshi, S. Yousef, S. Alinaghi, A. Haridass, I. Abd, E. Leite-Silva, V. Benson, Heather Grice, J. The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review. 2017 Journal Article http://hdl.handle.net/20.500.11937/47450 10.1016/j.jconrel.2016.12.022 Elsevier restricted |
| spellingShingle | Roberts, M. Mohammed, Y. Pastore, M. Namjoshi, S. Yousef, S. Alinaghi, A. Haridass, I. Abd, E. Leite-Silva, V. Benson, Heather Grice, J. Topical and cutaneous delivery using nanosystems |
| title | Topical and cutaneous delivery using nanosystems |
| title_full | Topical and cutaneous delivery using nanosystems |
| title_fullStr | Topical and cutaneous delivery using nanosystems |
| title_full_unstemmed | Topical and cutaneous delivery using nanosystems |
| title_short | Topical and cutaneous delivery using nanosystems |
| title_sort | topical and cutaneous delivery using nanosystems |
| url | http://hdl.handle.net/20.500.11937/47450 |