Covariance of Charged Amino Acids at Positions 322 and 440 of HIV-1 Env Contributes to Coreceptor Specificity of Subtype B Viruses, and Can Be Used to Improve the Performance of V3 Sequence-Based Coreceptor Usage Prediction Algorithms

Covariance of Charged Amino Acids at Positions 322 and 440 of HIV-1 Env Contributes to Coreceptor Specificity of Subtype B Viruses, and Can Be Used to Improve the Performance of V3 Sequence-Based Coreceptor Usage Prediction Algorithms

The ability to determine coreceptor usage of patient-derived human immunodeficiency virus type 1 (HIV-1) strains is clinically important, particularly for the administration of the CCR5 antagonist maraviroc. The envelope glycoprotein (Env) determinants of coreceptor specificity lie primarily within...

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Bibliographic Details
Main Authors: Cashin, K., Sterjovski, J., Harvey, K., Ramsland, Paul, Churchill, M., Gorry, P.
Format: Journal Article
Published: Public Library of Science 2014
Subjects:
covariance
amino acid sequencing
amino acid analysis
coreceptors
sequence analysis
HIV-1
sequence database
protein sequencing
Online Access:http://hdl.handle.net/20.500.11937/47237

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