Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique
The aim of this study was to prepare dextrin nanoparticles by emulsion cross-linking technique. The nanoparticles were prepared from nanoemulsion templates produced by high power ultrasonication. The influence of hydrophilic-lipophilic balance (HLB), surfactant type and concentration, water content,...
| Main Authors: | , , |
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| Format: | Journal Article |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/47091 |
| _version_ | 1848757738823221248 |
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| author | Manchun, S. Dass, Crispin Sriamornsak, P. |
| author_facet | Manchun, S. Dass, Crispin Sriamornsak, P. |
| author_sort | Manchun, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The aim of this study was to prepare dextrin nanoparticles by emulsion cross-linking technique. The nanoparticles were prepared from nanoemulsion templates produced by high power ultrasonication. The influence of hydrophilic-lipophilic balance (HLB), surfactant type and concentration, water content, and sonication time on the template size were examined in order to find optimal conditions for preparing dextrin nanoparticles. Nano-scaled templates were achieved when mixed surfactants (Span80/Tween80 and Span80/Brij30) at HLB 6 were used while using Span80 or other HLB values resulted in micron-sized templates. The smallest emulsion templates were achieved when using 7% (w/w) mixture of Span80/Tween80 at HLB 6, 15% (w/w) water, and sonication time of 30 minutes. The spherical dextrin nanoparticles possessed a slight negative charge on the surface. FTIR spectra confirmed that dextrin was cross-linked by glyoxal. This study developed a novel way of formulating dextrin nanoparticles, which may prove to be useful in future for drug delivery. |
| first_indexed | 2025-11-14T09:32:52Z |
| format | Journal Article |
| id | curtin-20.500.11937-47091 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:32:52Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-470912017-09-13T14:28:07Z Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique Manchun, S. Dass, Crispin Sriamornsak, P. emulsion crosslinking technique Dextrin ultrasonication nanoparticles The aim of this study was to prepare dextrin nanoparticles by emulsion cross-linking technique. The nanoparticles were prepared from nanoemulsion templates produced by high power ultrasonication. The influence of hydrophilic-lipophilic balance (HLB), surfactant type and concentration, water content, and sonication time on the template size were examined in order to find optimal conditions for preparing dextrin nanoparticles. Nano-scaled templates were achieved when mixed surfactants (Span80/Tween80 and Span80/Brij30) at HLB 6 were used while using Span80 or other HLB values resulted in micron-sized templates. The smallest emulsion templates were achieved when using 7% (w/w) mixture of Span80/Tween80 at HLB 6, 15% (w/w) water, and sonication time of 30 minutes. The spherical dextrin nanoparticles possessed a slight negative charge on the surface. FTIR spectra confirmed that dextrin was cross-linked by glyoxal. This study developed a novel way of formulating dextrin nanoparticles, which may prove to be useful in future for drug delivery. 2014 Journal Article http://hdl.handle.net/20.500.11937/47091 10.1016/j.carbpol.2013.09.049 Elsevier restricted |
| spellingShingle | emulsion crosslinking technique Dextrin ultrasonication nanoparticles Manchun, S. Dass, Crispin Sriamornsak, P. Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| title | Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| title_full | Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| title_fullStr | Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| title_full_unstemmed | Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| title_short | Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| title_sort | designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique |
| topic | emulsion crosslinking technique Dextrin ultrasonication nanoparticles |
| url | http://hdl.handle.net/20.500.11937/47091 |